{ "abstract": "The 6th edition of the World Health Organization Classification of Soft Tissue and Bone Tumors (STB6) integrates the latest scientific and molecular discoveries with decades of pathological expertise to establish a globally accepted common language for diagnosis and clinical behavior. In this volume, the “essential” and “desirable” diagnostic criteria have been refined, considering different resource settings, ensuring accuracy while maintaining flexibility. A tumor type (entity) is a tumor in which multiple parameters (eg, clinical, histopathological, and/or genetic features) differ from those of other tumor types. In total, 19 new entities met these criteria and were added. A subtype is different in at least one dimension from the main tumor type (clinical, histopathological, or genetic), preferably resulting in a different treatment or outcome. A morphological pattern (no longer “variant”) is important for pathologists to be aware of to facilitate recognition but is not associated with different clinical behavior. The classification was drafted by 203 editors and authors from 27 countries, representing genetics, medical oncology, surgical oncology, orthopedic surgery, and radiology, in addition to pathology. STB6 includes soft tissue tumors (n=116), bone tumors (n=46), vascular tumors of soft tissue and bone (n=18), undifferentiated spindle and round cell sarcomas (n=4), hematopoietic and dendritic cell neoplasms (n=6), and genetic syndromes (n=6). In total, 62 sarcomas are included. A consensus was reached among the expert editorial board. In this review, we highlight changes in tumor classification in STB6, including recently described tumor types, novel diagnostic markers, recent discoveries in molecular genetics, and improvements in prognostication.", "abstract_shown": true, "affiliations": [ "Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA", "Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands", "Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands", "Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY", "Department of Pathology, HOCH Health Ostschweiz, St. Gallen, Switzerland", "Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium", "CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent, Belgium", "Department of Diagnostic Sciences, Ghent University, Ghent, Belgium", "Research Foundation Flanders (FWO), Brussels, Belgium", "Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua School of Medicine, Padua, Italy", "Department of Cellular Pathology, University Hospitals Birmingham, Birmingham, United Kingdom", "Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN", "Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX", "Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD", "Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA", "Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan", "Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan", "Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China", "Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan", "Department of Medicine, Centre Léon Bérard and Université de Lyon, Lyon, France", "Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands", "Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy", "Department of Laboratory Medicine, Lund University, Lund, Sweden", "Department of Radiology, Royal Marsden Hospital, London, United Kingdom", "Department of Medical and Molecular Genetics and IU Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN", "Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE", "Department of Anatomical Pathology, St Vincent’s Hospital Sydney, University of New South Wales Sydney, University of Notre Dame, Sydney, Australia", "Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute (HBNI) University, Mumbai, India", "International Agency for Research on Cancer, World Health Organization, Lyon, France" ], "article_type": "review article", "arxiv": null, "author_total": 32, "authors": [ { "affs": [ 0 ], "name": "Jason L. Hornick" }, { "affs": [ 1, 2 ], "name": "Judith V.M.G. Bovee" }, { "affs": [ 3 ], "name": "Cristina R. Antonescu" }, { "affs": [ 4 ], "name": "Daniel Baumhoer" }, { "affs": [ 5, 6, 7, 8 ], "name": "David Creytens" }, { "affs": [ 9 ], "name": "Angelo P. Dei Tos" }, { "affs": [ 10 ], "name": "Cyril Fisher" }, { "affs": [ 11 ], "name": "Andrew L. Folpe" }, { "affs": [ 3 ], "name": "Meera Hameed" }, { "affs": [ 12 ], "name": "Alexander J. Lazar" }, { "affs": [ 13 ], "name": "Markku Miettinen" }, { "affs": [ 14 ], "name": "G. Petur Nielsen" }, { "affs": [ 15 ], "name": "Yoshinao Oda" }, { "affs": [ 16 ], "name": "Nasir Ud Din" }, { "affs": [ 17 ], "name": "Jian Wang" }, { "affs": [ 18 ], "name": "Akihiko Yoshida" }, { "affs": [ 19 ], "name": "Jean-Yves Blay" }, { "affs": [ 20 ], "name": "Johan L. Bloem" }, { "affs": [ 21 ], "name": "Alessandro Gronchi" }, { "affs": [ 22 ], "name": "Fredrik Mertens" }, { "affs": [ 23 ], "name": "Christina Messiou" }, { "affs": [ 24 ], "name": "Jennelle C. Hodge" }, { "affs": [ 25 ], "name": "Joseph D. Khoury" }, { "affs": [ 26 ], "name": "Andrew Field" }, { "affs": [ 27 ], "name": "Bharat Rekhi" }, { "affs": [ 28 ], "name": "Harshima Wijesinghe" }, { "affs": [ 28 ], "name": "Pavitratha Puspanathan" }, { "affs": [ 28 ], "name": "Fikret Dirilenoglu" }, { "affs": [ 28 ], "name": "Christine Giesen" }, { "affs": [ 28 ], "name": "Blanca I. Indave Ruiz" }, { "affs": [ 28 ], "name": "Dilani Lokuhetty" }, { "name": "Wendy Cooper" } ], "bibtex": "https://research.draconitic.com/paper/1epr50wcpdk6s.bib", "cited_by": 0, "doi": "10.1097/pas.0000000000002624", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13742349/", "id": "1epr50wcpdk6s", "issns": [ "0147-5185", "1532-0979" ], "landing_url": "https://doi.org/10.1097/pas.0000000000002624", "language": "en", "licence": "CC-BY-NC-ND-4.0", "licence_label": "CC BY-NC-ND 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Review Article" ], [ "openalex", "2730|Sarcoma Diagnosis and Treatment" ] ], "openalex": "W7220868412", "pdf_url": null, "pmcid": "PMC13742349", "pmid": "42839882", "published": "2026-10-07", "publisher": null, "ris": "https://research.draconitic.com/paper/1epr50wcpdk6s.ris", "sources": [ { "first_seen": "2026-11-10T12:23:12Z", "native_id": "PMC13742349", "source": "pmc", "url": "https://doi.org/10.1097/pas.0000000000002624" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2730|Sarcoma Diagnosis and Treatment", "subfield": "oncology" } ], "title": "The 2026 World Health Organization Classification of Tumors of Soft Tissue and Bone", "title_text": "The 2026 World Health Organization Classification of Tumors of Soft Tissue and Bone", "type": "peer-reviewed", "updated_at": "2026-11-10T12:23:12Z", "url": "https://research.draconitic.com/paper/1epr50wcpdk6s", "venue": "The American Journal of Surgical Pathology", "versions": [] }