{
  "abstract": "Background\n\nPatient-reported vitality is increasingly recognized as a prognostic factor in oncology. We evaluated whether the baseline vitality domain of the 36-item Short Form Health Survey (SF-36) predicts overall survival (OS) and progression-free survival (PFS) in patients with hematologic malignancies.Methods\n\nWe conducted an observational cohort study at a tertiary cancer center in Colombia, with prospective baseline assessment and outcomes ascertained from clinical records. Consecutive adults with advanced multiple myeloma, lymphoma, or acute leukemia completed the SF-36 vitality domain at enrollment and were followed for survival and disease progression.Results\n\nFifty-six patients were included: 31 with high vitality (score > 50) and 25 with low vitality (score ≤ 50). Low vitality was associated with worse Eastern Cooperative Oncology Group (ECOG) performance status and higher mortality (60% vs. 29%, p = 0.040). Median OS was 16 months in the low-vitality group versus not reached in the high-vitality group (log-rank p = 0.064). Median PFS was 10 versus 28 months (p = 0.041). In Cox regression, low vitality remained associated with a higher risk of death, with a hazard ratio (HR) of 2.46 (95% confidence interval (CI): 0.94-6.48; p = 0.068). As a continuous variable, each 10-point increase in vitality score was associated with a 17% reduction in mortality risk (HR: 0.83; 95% CI: 0.71-0.97; p = 0.032). Adding vitality improved prognostic discrimination, with the concordance index increasing from 0.63 to 0.71.Conclusions\n\nLow baseline vitality was associated with inferior survival outcomes and may provide incremental prognostic value beyond performance status in advanced hematologic malignancies. Prospective validation in larger cohorts is warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Research Group on Myeloma, Lymphoma, Leukemia, Transplantation, and Cell Therapy, Instituto Nacional de Cancerología, Bogotá, COL.",
    "Specialization Program in Pain Medicine and Palliative Care, Universidad de La Sabana, Chía, COL.",
    "Palliative Care Unit, Instituto Nacional de Cancerología, Bogotá, COL."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Humberto Martínez Cordero"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Laura C Bermúdez Rojas"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Dolli Y Cáceres Gálindez"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Laura Cuéllar Valencia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1f1y69e8vh6sx.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116984",
  "fulltext_url": "https://europepmc.org/articles/PMC13712484",
  "id": "1f1y69e8vh6sx",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948798",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Hematology"
    ],
    [
      "heading",
      "Oncology"
    ],
    [
      "heading",
      "Palliative Care"
    ],
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7214530186",
  "pdf_url": "https://europepmc.org/articles/PMC13712484?pdf=render",
  "pmcid": "PMC13712484",
  "pmid": "42948798",
  "published": "2026-09-26",
  "publisher": "Cureus Inc.",
  "ris": "https://research.draconitic.com/paper/1f1y69e8vh6sx.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:35Z",
      "native_id": "MED:42948798",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948798"
    },
    {
      "first_seen": "2026-10-31T12:23:02Z",
      "native_id": "PMC13712484",
      "source": "pmc",
      "url": "https://doi.org/10.7759/cureus.116984"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Oncology",
      "subfield": "oncology"
    }
  ],
  "title": "Vitality as a Prognostic Biomarker in Hematologic Malignancies: Association With Overall Survival and Progression-Free Survival.",
  "title_text": "Vitality as a Prognostic Biomarker in Hematologic Malignancies: Association With Overall Survival and Progression-Free Survival.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:23:02Z",
  "url": "https://research.draconitic.com/paper/1f1y69e8vh6sx",
  "venue": "Cureus",
  "versions": []
}