{
  "abstract": "A 76-year-old woman was diagnosed with acromegaly and underwent resection of a transsphenoidal pituitary tumor. Central hypothyroidism was detected before surgery and the patient was treated with levothyroxine. Insulin-like growth factor-1 (IGF-1) levels remained abnormal after surgery. Follow-up showed an increase in free thyroxine levels even after discontinuation of levothyroxine; thereafter, Marine-Lenhart syndrome was diagnosed. The initiation of treatment with a somatostatin analog for acromegaly and thiamazole for Marine-Lenhart syndrome was followed by normalization of IGF-1 levels and thyroid function test results. Coexistent thyrotoxicosis is rare in patients with acromegaly; therefore, attention should be paid to elderly patients, as they exhibit only a few symptoms.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Momo Saito"
    },
    {
      "name": "Yosuke Okada"
    },
    {
      "name": "Fumi Uemura"
    },
    {
      "name": "Yoshiya Tanaka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1f7twwpmsvq2x.bib",
  "cited_by": 1,
  "doi": "10.2169/internalmedicine.5550-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5550-25/_article",
  "id": "1f7twwpmsvq2x",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5550-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2712|Pituitary Gland Disorders and Treatments"
    ]
  ],
  "openalex": "W4417441955",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_5550-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1f7twwpmsvq2x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.5550-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5550-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Pituitary Gland Disorders and Treatments",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Development of Marine-Lenhart Syndrome during the Course of Acromegaly",
  "title_text": "Development of Marine-Lenhart Syndrome during the Course of Acromegaly",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/1f7twwpmsvq2x",
  "venue": "Internal Medicine",
  "versions": []
}