{
  "abstract": "Chronic and complex wounds frequently exhibit delayed healing associated with persistent inflammation, microbial burden and biofilm formation. This prospective observational case series describes wound-healing outcomes associated with adjunctive use of a thermo-reversible antimicrobial wound gel (TRG) in 17 adult patients with chronic wounds treated in an outpatient setting. A total of 28 wounds were analysed over up to 12 weeks using clinically relevant endpoints including percentage area reduction (PAR), wound bed tissue composition, exudate level, tissue oxygenation and patient-reported pain. Mean PAR was 43.9% at the wound level and 42.7% at the patient level. The proportion of wounds demonstrating epithelial tissue increased from 25.0% to 68.8%, while necrotic tissue decreased from 25.0% to 12.5%. Low exudate increased from 41.2% at baseline to 64.7% at final assessment. Mean pain scores decreased from 4.76 to 2.18 (p = 0.0125). In patients with available tissue oxygenation data, change in oxygenation was positively correlated with PAR (p = 0.011). These findings suggest that adjunctive use of the TRG was associated with improvement across multiple clinical outcomes in a real-world population of patients with chronic and complex wounds and support further evaluation in controlled studies.",
  "abstract_shown": true,
  "affiliations": [
    "Colborne Clinic, Colborne, Ontario, Canada.",
    "Kane Biotech, Winnipeg, Manitoba, Canada."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Iris Noland"
    },
    {
      "affs": [
        1
      ],
      "name": "Miloslav Sailer",
      "orcid": "0009-0008-7208-5265"
    },
    {
      "affs": [
        1
      ],
      "name": "Jeyachchandran Visvalingam",
      "orcid": "0000-0002-6099-409X"
    },
    {
      "affs": [
        1
      ],
      "name": "Rohan Pointer"
    },
    {
      "affs": [
        1
      ],
      "name": "Robert B Huizinga",
      "orcid": "0000-0001-8703-7655"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1fgh42r3qn0d7.bib",
  "cited_by": 0,
  "doi": "10.1111/iwj.71081",
  "fulltext_url": "https://europepmc.org/articles/PMC13720227",
  "id": "1fgh42r3qn0d7",
  "issns": [
    "1742-4801",
    "1742-481X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958607",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Investigative Study"
    ],
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7224928828",
  "pdf_url": "https://europepmc.org/articles/PMC13720227?pdf=render",
  "pmcid": "PMC13720227",
  "pmid": "42958607",
  "published": "2026-10-29",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/1fgh42r3qn0d7.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:36Z",
      "native_id": "MED:42958607",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958607"
    },
    {
      "first_seen": "2026-11-03T12:21:09Z",
      "native_id": "PMC13720227",
      "source": "pmc",
      "url": "https://doi.org/10.1111/iwj.71081"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Multidimensional Wound Healing Outcomes in Chronic and Complex Wounds: A Real-World Case Series With a Thermoreversible Wound Gel.",
  "title_text": "Multidimensional Wound Healing Outcomes in Chronic and Complex Wounds: A Real-World Case Series With a Thermoreversible Wound Gel.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:09Z",
  "url": "https://research.draconitic.com/paper/1fgh42r3qn0d7",
  "venue": "International wound journal",
  "versions": []
}