{
  "abstract": "High-temperature Daqu (HTD), the essential solid-state fermentation starter for premium Moutai-flavor Baijiu , reaches a peak temperature of 60–65 °C driven by microbial metabolic heat; yet the detailed metabolic mechanism underlying the Bacillus – Pediococcus thermogenic synergy remains largely unresolved. This study integrated isothermal microcalorimetry, time-resolved transcriptomics, and untargeted metabolomics to decipher this cooperative thermogenesis under heat stress, with further validation in a simulated HTD-making system. A network of metabolic interaction and flux redirection was identified, in which heat-induced cell turnover releases cellular nitrogen into a shared pool, and Pediococcus contributes aromatic amino acid biosynthesis that supports respiratory heat output in Bacillus . Chorismate was identified as a central metabolic branch point, where flux is redirected toward tyrosine and menaquinone biosynthesis to sustain metabolic turnover, enhance electron transport efficiency, and alleviate oxidative damage. These findings provide a theoretical basis for precise and standardized industrial production of HTD.",
  "abstract_shown": true,
  "affiliations": [
    "Guizhou Key Laboratory of Microbial Resources Exploration in Fermentation Industry, Kweichow Moutai Group, Renhuai 564500, Guizhou, China; Guizhou Provincial Laboratory of Biomanufacturing, Kweichow Moutai Group, Renhuai 564500, Guizhou, China",
    "Guizhou Key Laboratory of Microbial Resources Exploration in Fermentation Industry, Kweichow Moutai Group, Renhuai 564500, Guizhou, China",
    "School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, China",
    "School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, China; Co-Corresponding author.",
    "School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, China; Corresponding author."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Huabin Tu"
    },
    {
      "affs": [
        0
      ],
      "name": "Guanyu Zhou"
    },
    {
      "affs": [
        1
      ],
      "name": "Fanggen Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Fan Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Liangqiang Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianjun Lu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jianghua Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Yanfeng Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Jian Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1fhwq64vh1s6h.bib",
  "cited_by": 0,
  "doi": "10.1016/j.fochx.2026.104599",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S259015752601120X",
  "id": "1fhwq64vh1s6h",
  "issns": [
    "2590-1575"
  ],
  "landing_url": "https://doi.org/10.1016/j.fochx.2026.104599",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "lcc",
      "TP368-456"
    ],
    [
      "lcc",
      "TX341-641"
    ],
    [
      "openalex",
      "1106|Fermentation and Sensory Analysis"
    ]
  ],
  "openalex": "W7222756034",
  "pdf_url": "https://europepmc.org/articles/PMC13716998?pdf=render",
  "pmcid": null,
  "pmid": "42959424",
  "published": "2026-10-16",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/1fhwq64vh1s6h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:30Z",
      "native_id": "1ffe8dab470446eba11b0dfec074585a",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.fochx.2026.104599"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42959424",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959424"
    },
    {
      "first_seen": "2026-11-02T12:21:24Z",
      "native_id": "PMC13716998",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.fochx.2026.104599"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:TX341-641",
      "subfield": "nutrition"
    }
  ],
  "title": "Interaction-driven chorismate metabolic reprogramming underlies",
  "title_text": "Interaction-driven chorismate metabolic reprogramming underlies",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:24Z",
  "url": "https://research.draconitic.com/paper/1fhwq64vh1s6h",
  "venue": "Food Chemistry: X",
  "versions": []
}