{
  "abstract": "Whole-genome doubling (WGD) is common across human cancers and is associated with tumour progression and adverse clinical outcomes. However, how genome-doubled tumours evolve across diverse cancer types remains poorly understood. Here we characterize WGD-associated tumour evolution by integrating genomic analyses of 41,332 tumours from 12 cancer types with evolutionary timing and multi-omic data. Several canonical driver mutations generally preceded WGD when both occurred, as did the onset of homologous recombination deficiency-associated mutagenesis. Notably, post-WGD chromosome-arm losses showed substantially weaker cancer-type dependence than pre-WGD losses, with 61-75% less variance explained by cancer type. Beyond chromosomal evolution, WGD+ tumours showed reduced interferon-response and HLA antigen-presentation programmes linked to epigenetic remodelling, without disproportionate enrichment of genetic immune-escape alterations. Our findings highlight WGD as a recurrent evolutionary transition associated with altered chromosomal evolution and epigenetically linked immune adaptation across cancers.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2611.01897",
  "author_total": 12,
  "authors": [
    {
      "name": "Yangyang Zhang"
    },
    {
      "name": "Haiming Li"
    },
    {
      "name": "Xiaoyu Zhao"
    },
    {
      "name": "Zilong Wang"
    },
    {
      "name": "Yongqi Chen"
    },
    {
      "name": "Sumeng Yang"
    },
    {
      "name": "Shaocong Mo"
    },
    {
      "name": "Jinming Li"
    },
    {
      "name": "Xiaohua Wu"
    },
    {
      "name": "Xu Wang"
    },
    {
      "name": "Shuo Wang"
    },
    {
      "name": "Qinhao Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1frcx19pm2rc3.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2611.01897",
  "fulltext_url": null,
  "id": "1frcx19pm2rc3",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2611.01897",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "q-bio.GN"
    ],
    [
      "arxiv",
      "q-bio.PE"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://arxiv.org/pdf/2611.01897",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1frcx19pm2rc3.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:15Z",
      "native_id": "2611.01897",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2611.01897"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "arxiv:q-bio.PE",
      "subfield": "evolutionary-biology"
    },
    {
      "field": "biology",
      "origin": "arxiv:q-bio.GN",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Evolutionary characterization of whole-genome doubling across human cancers",
  "title_text": "Evolutionary characterization of whole-genome doubling across human cancers",
  "type": "preprint",
  "updated_at": "2026-11-05T15:20:29Z",
  "url": "https://research.draconitic.com/paper/1frcx19pm2rc3",
  "venue": "arXiv",
  "versions": []
}