{
  "abstract": "Importance\n\nFerritin 2 (Fer2) is a well-established candidate antigen for anti-tick vaccines, but few studies have investigated the potential of Hyalomma anatolicum Fer2 as an antigenic peptide.Objective\n\nTo characterize the H. anatolicum fer 2 coding sequence, conserved motifs, predicted structure, and linear B-cell epitopes.Methods\n\nThe complete coding sequence region of the H. anatolicum Fer2 gene was amplified by polymerase chain reaction. The biological properties and effective antigenic peptide of H. anatolicum Fer2 protein were analyzed.Results\n\nThe Fer2 sequence of H. anatolicum collected showed the highest similarity to that of H. anatolicum from Turpan, Xinjiang (accession No. ALJ92580.1), and the phylogenetic analysis accurately classified Fer2 among the different tick species. The biological property results showed that H. anatolicum Fer2 is a non-transmembrane protein with a signal peptide and a typical Fer protein structure. Motif analysis showed that different tick 5 motifs were in random combinations, but motifs 1, 2, and 4 were contained in all tick Fer2 proteins. Correspondence existed between motifs and antigens, with motif 1 containing the highest-scoring antigenic epitope.Conclusions and relevance\n\nH. anatolicum fer 2 motif 1 contains a conserved, high-scoring predicted linear B-cell epitope and warrants experimental immunogenicity and protection studies before consideration as an anti-tick vaccine peptide.",
  "abstract_shown": true,
  "affiliations": [
    "College of Animal Medicine, Xinjiang Agricultural University, Urumqi 830052, China.",
    "Xinjiang Key Laboratory of Herbivore New Drug Research and Creation, Urumqi 830052, China.",
    "College of Animal Science and Technology, Xinjiang Agricultural Vocational and Technical University, Changji 831100, China. caishanlivet@outlook.com.",
    "Xinjiang Key Laboratory of Herbivore New Drug Research and Creation, Urumqi 830052, China. 939667709@qq.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xueqing Zhao",
      "orcid": "0009-0006-0786-3900"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zeyun Cui",
      "orcid": "0009-0003-2101-1307"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Na Zhou",
      "orcid": "0009-0000-4508-7531"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuqian Deng",
      "orcid": "0009-0007-9058-9304"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Licui Wen",
      "orcid": "0009-0005-9147-4651"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenying Dang",
      "orcid": "0009-0003-6391-0837"
    },
    {
      "affs": [
        2
      ],
      "name": "Caishan Li",
      "orcid": "0009-0006-4202-7289"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Bayinchahan Gailike",
      "orcid": "0009-0006-5355-8122"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1fyfghj3yptjk.bib",
  "cited_by": 0,
  "doi": "10.4142/jvs.25152",
  "fulltext_url": "https://europepmc.org/articles/PMC13655566",
  "id": "1fyfghj3yptjk",
  "issns": [
    "1229-845X",
    "1976-555X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42847793",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|vaccines and immunoinformatics approaches"
    ]
  ],
  "openalex": "W7170090771",
  "pdf_url": "https://europepmc.org/articles/PMC13655566?pdf=render",
  "pmcid": "PMC13655566",
  "pmid": "42847793",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1fyfghj3yptjk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42847793",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42847793"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|vaccines and immunoinformatics approaches",
      "subfield": "molecular-biology"
    }
  ],
  "title": "In silico characterization of ferritin 2 conserved motifs and B-cell epitopes in Hyalomma anatolicum.",
  "title_text": "In silico characterization of ferritin 2 conserved motifs and B-cell epitopes in Hyalomma anatolicum.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/1fyfghj3yptjk",
  "venue": "Journal of veterinary science",
  "versions": []
}