{
  "abstract": "Antibiotic tolerance is an increasingly recognised contributor to treatment failure. Integrating genomics with laboratory evolution and functional screening has shifted emphasis from studying tolerance as a transient, non-heritable phenotype to recognising its genetic underpinnings. These approaches reveal pathways that shape antibiotic survival beyond dormant-cell models. However, most insights derive from laboratory systems, leaving their clinical relevance unresolved. In this review, we discuss advances in genome-wide analyses of tolerance and their potential to identify candidate genes and variants in patient-derived isolates, resolve genetic architecture and epistasis, and uncover influences on resistance evolution, ultimately advancing the development of diagnostic and therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Carolin M. Kobras",
      "orcid": "0000-0003-4393-5829"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1g1vmtw5v5fca.bib",
  "cited_by": 0,
  "doi": "10.1186/s13059-026-04257-x",
  "fulltext_url": null,
  "id": "1g1vmtw5v5fca",
  "issns": [
    "1474-760X"
  ],
  "landing_url": "https://link.springer.com/10.1186/s13059-026-04257-x",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Bacterial Genetics and Biotechnology"
    ]
  ],
  "openalex": "W7216569833",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/1g1vmtw5v5fca.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:06Z",
      "native_id": "10.1186/s13059-026-04257-x",
      "source": "crossref",
      "url": "https://link.springer.com/10.1186/s13059-026-04257-x"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Bacterial Genetics and Biotechnology",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Transforming antibiotic tolerance research through genomics",
  "title_text": "Transforming antibiotic tolerance research through genomics",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:06Z",
  "url": "https://research.draconitic.com/paper/1g1vmtw5v5fca",
  "venue": "Genome Biology",
  "versions": []
}