{
  "abstract": "Background\n\nDeep brain stimulation (DBS) of the ventral intermediate nucleus and posterior subthalamic area (VIM/PSA) in Essential Tremor (ET) and the subthalamic nucleus (STN) in Parkinson's disease (PD) are established treatments for tremor. To achieve maximum tremor control, increasing stimulation frequency beyond 130 Hz is part of clinical practice, but lacks scientific evidence.Objective\n\nTo compare tremor suppression under total electrical energy delivered (TEED)-equivalent stimulation at 130 versus 185 Hz in VIM/PSA-DBS for ET and STN-DBS for PD.Methods\n\nIn this prospective, double-blind study, acute DBS effects were assessed in 18 people with ET (n = 29 hemispheres), and 25 people with PD (n = 30 hemispheres). Tremor-suppressive effects, evaluated by accelerometry, were compared with TEED-equivalent stimulation at 130 and 185 Hz using linear mixed-effects models, explorative pairwise comparisons, and equivalency testing.Results\n\nLinear mixed-effects models revealed no significant effect of stimulation frequency on tremor improvement in both cohorts. Pairwise comparisons showed no consistent differences in total tremor improvement with TEED-equivalent 130 Hz vs 185 Hz DBS. Post-hoc equivalence testing confirmed equivalence of stimulation frequencies under TEED-equivalent conditions within a ±20% margin of relative tremor improvement.Conclusion\n\nThis study provides Level II evidence that a higher stimulation frequency of 185 Hz does not offer additional benefit in deep brain stimulation for tremor in VIM/PSA for Essential Tremor or in the STN for Parkinson's Disease in the acute setting and supports 130 Hz as the standard stimulation frequency for tremor suppression.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.",
    "Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.",
    "Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM3)-Research Center Jülich, Jülich, Germany.",
    "Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Christina van der Linden",
      "orcid": "0000-0003-2091-4638"
    },
    {
      "affs": [
        0
      ],
      "name": "Peer Trapp",
      "orcid": "0009-0004-9424-8345"
    },
    {
      "affs": [
        0
      ],
      "name": "Till A Dembek",
      "orcid": "0000-0001-7023-146X"
    },
    {
      "affs": [
        0
      ],
      "name": "Charlotte Schedlich-Teufer",
      "orcid": "0000-0002-4465-1986"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gregor A Brandt",
      "orcid": "0000-0002-9984-2069"
    },
    {
      "affs": [
        0
      ],
      "name": "Hannah Jergas"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Gereon R Fink",
      "orcid": "0000-0002-8230-1856"
    },
    {
      "affs": [
        3
      ],
      "name": "Veerle Visser-Vandewalle",
      "orcid": "0000-0002-5274-7929"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael T Barbe",
      "orcid": "0000-0003-1149-8054"
    },
    {
      "affs": [
        0
      ],
      "name": "Jan Niklas Petry-Schmelzer",
      "orcid": "0000-0003-0749-3840"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1ga0jynjc75rg.bib",
  "cited_by": 0,
  "doi": "10.1002/mdc3.70886",
  "fulltext_url": "https://europepmc.org/articles/PMC13728422",
  "id": "1ga0jynjc75rg",
  "issns": [
    "2330-1619"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972941",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2728|Deep Brain Stimulation and Movement Disorders"
    ]
  ],
  "openalex": "W7163370166",
  "pdf_url": "https://europepmc.org/articles/PMC13728422?pdf=render",
  "pmcid": "PMC13728422",
  "pmid": "42972941",
  "published": "2026-11-02",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/1ga0jynjc75rg.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42972941",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972941"
    },
    {
      "first_seen": "2026-11-07T12:21:25Z",
      "native_id": "PMC13728422",
      "source": "pmc",
      "url": "https://doi.org/10.1002/mdc3.70886"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Deep Brain Stimulation and Movement Disorders",
      "subfield": "neurology"
    }
  ],
  "title": "No Additional Benefit of 185 Hz Versus 130 Hz at Equivalent Energy in Deep Brain Stimulation for Tremor: A Randomized Prospective Clinical Trial.",
  "title_text": "No Additional Benefit of 185 Hz Versus 130 Hz at Equivalent Energy in Deep Brain Stimulation for Tremor: A Randomized Prospective Clinical Trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:25Z",
  "url": "https://research.draconitic.com/paper/1ga0jynjc75rg",
  "venue": "Movement disorders clinical practice",
  "versions": []
}