{
  "abstract": "{middle dot}The pathophysiology of ALS caused by mutant SOD1 remains unclear. {middle dot}We previously demonstrated, using the BioID2-EGFP sandwich expression system in cultured cells, that the Ile35 residue of ALS-linked mutant SOD1 promotes its aggregate formation. {middle dot}However, the precise role of the SOD1 Ile35 residue in aggregate formation and neurodegeneration in vivo remained unclear. {middle dot}Drosophila expressing BioID2-G93A-EGFP demonstrated aggregate formation and eye degeneration with reduced eye size, whereas those expressing BioID2-G93A/I35S-EGFP showed less of these phenotypes. {middle dot}These findings highlight the crucial role of the Ile35 residue of ALS-linked SOD1 in aggregate formation and neurodegeneration in vivo.",
  "abstract_shown": true,
  "affiliations": [
    "Hyogo Medical University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "K. Yano"
    },
    {
      "name": "Y. Fujino"
    },
    {
      "name": "Y. Nagai"
    },
    {
      "affs": [
        0
      ],
      "name": "N. Fujiwara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1gb9amczdr9k2.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.13.751333",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751333v1.full",
  "id": "1gb9amczdr9k2",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751333v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2728|Amyotrophic Lateral Sclerosis Research"
    ]
  ],
  "openalex": "W7213762250",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751333v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1gb9amczdr9k2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:19Z",
      "native_id": "10.64898/2026.09.13.751333",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751333v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Ile35 residue of SOD1 plays a key role in aggregate formation and eye degeneration in a Drosophila model of ALS",
  "title_text": "Ile35 residue of SOD1 plays a key role in aggregate formation and eye degeneration in a Drosophila model of ALS",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:19Z",
  "url": "https://research.draconitic.com/paper/1gb9amczdr9k2",
  "venue": "bioRxiv",
  "versions": []
}