{
  "abstract": "Bat sarbecoviruses differ in the range of mammalian ACE2 receptors they can use, complicating predictions of spillover risk. Two new studies in PLOS Biology link receptor breadth with antigenic relatedness and reveal conserved spike epitopes targetable by antibodies.\n\nBat sarbecoviruses differ in the range of mammalian ACE2 receptors they can use, complicating predictions of spillover risk. This Primer comments on two new studies in PLOS Biology that link receptor breadth with antigenic relatedness and reveal conserved spike epitopes targetable by antibodies.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Pathogen Research, The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America"
  ],
  "article_type": "Primer",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Matthew B. Frieman",
      "orcid": "0000-0003-0107-0775"
    }
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  "cited_by": 0,
  "doi": "10.1371/journal.pbio.3004071",
  "fulltext_url": "https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004071",
  "id": "1gtp1r1k7gm5a",
  "issns": [
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    "1544-9173"
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  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Amniotes"
    ],
    [
      "heading",
      "Animals"
    ],
    [
      "heading",
      "Antibodies"
    ],
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      "Bats"
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    [
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      "Biochemistry"
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      "heading",
      "Biology and Life Sciences"
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      "heading",
      "Biology and life sciences"
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      "heading",
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    [
      "heading",
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      "heading",
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    ],
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      "heading",
      "Coronaviruses"
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      "heading",
      "Eukaryota"
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      "heading",
      "Evolutionary Biology"
    ],
    [
      "heading",
      "Immune Physiology"
    ],
    [
      "heading",
      "Immune System Proteins"
    ],
    [
      "heading",
      "Immunology"
    ],
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      "heading",
      "Mammals"
    ],
    [
      "heading",
      "Medical Microbiology"
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    [
      "heading",
      "Medical microbiology"
    ],
    [
      "heading",
      "Medicine and Health Sciences"
    ],
    [
      "heading",
      "Medicine and health sciences"
    ],
    [
      "heading",
      "Membrane Proteins"
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      "heading",
      "Microbial Evolution"
    ],
    [
      "heading",
      "Microbial Pathogens"
    ],
    [
      "heading",
      "Microbial pathogens"
    ],
    [
      "heading",
      "Microbiology"
    ],
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      "heading",
      "Monoclonal Antibodies"
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      "heading",
      "Organismal Evolution"
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      "heading",
      "Organisms"
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    [
      "heading",
      "Pathogens"
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      "heading",
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    [
      "heading",
      "Pathology and laboratory medicine"
    ],
    [
      "heading",
      "Physiology"
    ],
    [
      "heading",
      "Primer"
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    [
      "heading",
      "Proteins"
    ],
    [
      "heading",
      "RNA viruses"
    ],
    [
      "heading",
      "SARS CoV 2"
    ],
    [
      "heading",
      "SARS coronavirus"
    ],
    [
      "heading",
      "Vertebrates"
    ],
    [
      "heading",
      "Viral Evolution"
    ],
    [
      "heading",
      "Viral Pathogens"
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    [
      "heading",
      "Viral Structure"
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    [
      "heading",
      "Viral pathogens"
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    [
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      "Virions"
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    [
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      "Virology"
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    [
      "heading",
      "Viruses"
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    [
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      "2725|SARS-CoV-2 and COVID-19 Research"
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      "/Biology and life sciences/Biochemistry/Proteins/Immune system proteins/Antibodies"
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    ],
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    ],
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      "plos",
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    ],
    [
      "plos",
      "/Biology and life sciences/Zoology/Animals/Vertebrates/Amniotes/Mammals/Bats"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune system proteins/Antibodies"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune system proteins/Antibodies/Monoclonal antibodies"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Coronaviruses"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Coronaviruses/SARS coronavirus/SARS CoV 2"
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  "openalex": "W7223973875",
  "pdf_url": "https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3004071&type=printable",
  "pmcid": "PMC13712697",
  "pmid": "42945334",
  "published": "2026-10-27",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/1gtp1r1k7gm5a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.1371/journal.pbio.3004071",
      "source": "plos",
      "url": "https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004071"
    },
    {
      "first_seen": "2026-10-31T12:23:13Z",
      "native_id": "PMC13712697",
      "source": "pmc",
      "url": "https://doi.org/10.1371/journal.pbio.3004071"
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  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:Biochemistry",
      "subfield": "general"
    },
    {
      "field": "biology",
      "origin": "heading:Cell Biology",
      "subfield": "cell-biology"
    },
    {
      "field": "biology",
      "origin": "heading:Evolutionary Biology",
      "subfield": "evolutionary-biology"
    },
    {
      "field": "biology",
      "origin": "plos:immunology",
      "subfield": "immunology"
    },
    {
      "field": "biology",
      "origin": "plos:microbiology",
      "subfield": "microbiology"
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  ],
  "title": "Conserved spike epitopes persist in generalist bat sarbecoviruses",
  "title_text": "Conserved spike epitopes persist in generalist bat sarbecoviruses",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:23:13Z",
  "url": "https://research.draconitic.com/paper/1gtp1r1k7gm5a",
  "venue": "PLOS Biology",
  "versions": []
}