{
  "abstract": "Background:: Bioresorbable vascular scaffolds (BVS) were developed to address some limitations associated with permanent metallic drug-eluting stents (DES), but the comparative safety and efficacy of these scaffolds remain uncertain.\n\nMethods:: We conducted a systematic review and meta-analysis of randomized and observational studies comparing BVS with contemporary DES in patients with coronary artery disease. The primary outcome was the composite clinical endpoint at 1-year. Secondary outcomes included mortality, myocardial infarction (MI), revascularization, thrombosis, and angiographic measures. Outcomes at 2, 3, and 5 years were analyzed separately. Trial sequential analysis (TSA) was used to assess the robustness of the evidence for the primary outcome.\n\nResults:: A total of 51 studies (69 reports) were included. At 1 year, BVS was associated with a higher risk of the composite clinical endpoint than DES (risk ratio (RR) 1.11, 95% confidence interval (CI 1.00–1.22)), mainly driven by increased risks of MI, target lesion revascularization, and thrombosis. In contrast, all-cause and cardiac mortality did not differ significantly between groups. TSA showed that although the cumulative Z-curve reached the required information size, the Z-score did not cross the trial sequential monitoring boundary, indicating that the evidence for the primary endpoint remained inconclusive. During mid- and long-term follow-up, BVS remained associated with higher risks of ischemic events and repeat revascularization, without a survival benefit. Angiographic analyses showed greater late lumen loss, smaller minimal lumen diameter, and greater diameter stenosis with BVS.\n\nConclusions:: Compared with contemporary DES, BVS appears to confer a higher ischemic risk without a long-term mortality benefit. Contemporary DES remains the preferred revascularization strategy.",
  "abstract_shown": true,
  "affiliations": [
    "Interventional Center of Valve Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China"
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yue Yu",
      "orcid": "0009-0004-5005-3861"
    },
    {
      "affs": [
        0
      ],
      "name": "Ke Shang",
      "orcid": "0009-0006-9521-3042"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuemiao Jiao",
      "orcid": "0009-0007-4366-6290"
    },
    {
      "affs": [
        0
      ],
      "name": "Sanshuai Chang",
      "orcid": "0000-0001-5589-9867"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Li",
      "orcid": "0000-0002-6973-1333"
    },
    {
      "affs": [
        0
      ],
      "name": "Guangyuan Song",
      "orcid": "0000-0002-7868-6132"
    },
    {
      "affs": [
        0
      ],
      "name": "Chengqian Yin",
      "orcid": "0009-0009-9650-4978"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1gw41ea0xd790.bib",
  "cited_by": 0,
  "doi": "10.31083/rcm51636",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732709/",
  "id": "1gw41ea0xd790",
  "issns": [
    "1530-6550",
    "2153-8174"
  ],
  "landing_url": "https://doi.org/10.31083/rcm51636",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "2705|Coronary Interventions and Diagnostics"
    ]
  ],
  "openalex": "W7225259340",
  "pdf_url": "https://storage.imrpress.com/IMR/2112375958871531500/application/2153-8174-27-10-51636.pdf",
  "pmcid": "PMC13732709",
  "pmid": "42985635",
  "published": "2026-10-20",
  "publisher": "IMR Press",
  "ris": "https://research.draconitic.com/paper/1gw41ea0xd790.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:38Z",
      "native_id": "PMC13732709",
      "source": "pmc",
      "url": "https://doi.org/10.31083/rcm51636"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Coronary Interventions and Diagnostics",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Efficacy and Safety of Bioresorbable Vascular Scaffolds Versus Contemporary Drug-Eluting Stents in Coronary Artery Disease: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis",
  "title_text": "Efficacy and Safety of Bioresorbable Vascular Scaffolds Versus Contemporary Drug-Eluting Stents in Coronary Artery Disease: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:38Z",
  "url": "https://research.draconitic.com/paper/1gw41ea0xd790",
  "venue": "Reviews in Cardiovascular Medicine",
  "versions": []
}