{
  "abstract": "Introduction: Lymphatic filariasis is a major public health burden, particularly in endemic regions, with millions suffering from chronic lymphoedema and hydrocele. While mass drug administration aims to restrict transmission, effective morbidity management remains a significant challenge. Homoeopathy has reported potential in managing lymphoedema, yet evidence in cases of grade III and IV lymphoedema is limited.\n\nMethods: This open-label, exploratory, interventional study, conducted at the Regional Research Institute for Homoeopathy, Puri, Odisha, India, aimed to evaluate the effects of individualized homoeopathic medicines in managing grade III/IV unilateral/bilateral lower-limb lymphoedema associated with lymphatic filariasis. Outcomes included changes in limb circumference (Australasian Lymphology Association standards), limb volume (Water Displacement Method), health-related quality of life (7D5L scale), dermatological changes (Dermatology Life Quality Index), acute adenolymphangitis episodes, skin health, and serological markers over one year. A total of 104 eligible participants were enrolled, and followed-up monthly for one year. 61 participants dropped out of the study, and 43 participants successfully completed all the follow-ups.\n\nResults: Statistically significant improvements were observed in quality of life and dermatological indices (p-value < 0.0001), along with alleviation of limb volume. Decreased Og4C3 and TNF-α levels, resolution of entry lesions and ulcers, and reduction in occurrence of fungal infections were documented.\n\nDiscussion: The study demonstrated the potential benefits of homoeopathy in managing advanced filarial lymphoedema by improving quality of life. Further controlled studies with larger sample are warranted.\n\nClinical trial registration: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjY2NzE=&Enc=&userName=, identifier CTRI/2018/06/014591.",
  "abstract_shown": true,
  "affiliations": [
    "Central Council for Research in Homoeopathy, Ministry of Ayush, Government of India, New Delhi, India",
    "National Institute of Homoeopathy, Ministry of Ayush, Government of India, New Delhi, India",
    "Regional Research Institute for Homoeopathy, Puri, Odisha, India",
    "Drug Proving Unit (Homoeopathy), Bhubaneswar, Odisha, India",
    "Department of Applied Statistics and Data Science, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, India",
    "ICMR-Regional Medical Research Centre, Bhubaneswar, Department of Health Research, Ministry of Health & Family Welfare, Government of India, Odisha, India",
    "Manipal Institute of Virology, Manipal Academy of Higher Education, Manipal, Karnataka, India"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
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        0
      ],
      "name": "Panaparambil Azis Suhana"
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        1
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      "name": "Jain Vij Shruti"
    },
    {
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        3
      ],
      "name": "Sujata Choudhury"
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    {
      "affs": [
        0
      ],
      "name": "Jaya Gupta"
    },
    {
      "affs": [
        4
      ],
      "name": "Vasudeva Guddattu"
    },
    {
      "affs": [
        5
      ],
      "name": "Prakash Kumar Sahoo"
    },
    {
      "affs": [
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      ],
      "name": "Charu Sehgal"
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    {
      "affs": [
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      ],
      "name": "Preeti Bhandari"
    },
    {
      "affs": [
        2
      ],
      "name": "Monalisha Das"
    },
    {
      "affs": [
        6
      ],
      "name": "Prasad Varamballi"
    },
    {
      "affs": [
        0
      ],
      "name": "Subhash Kaushik"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1h2asw9zhfvpn.bib",
  "cited_by": 0,
  "doi": "10.3389/fpara.2026.1939673",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736774/",
  "id": "1h2asw9zhfvpn",
  "issns": [
    "2813-2424"
  ],
  "landing_url": "https://doi.org/10.3389/fpara.2026.1939673",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Trial"
    ],
    [
      "openalex",
      "2725|Parasitic Diseases Research and Treatment"
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  "openalex": "W7223188762",
  "pdf_url": "https://www.frontiersin.org/journals/parasitology/articles/10.3389/fpara.2026.1939673/pdf",
  "pmcid": "PMC13736774",
  "pmid": "42991261",
  "published": "2026-10-22",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/1h2asw9zhfvpn.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:09Z",
      "native_id": "PMC13736774",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fpara.2026.1939673"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Parasitic Diseases Research and Treatment",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Evaluating the impact of homoeopathy in managing the morbidity associated with grade III and IV lower limb lymphoedema in adults with lymphatic filariasis",
  "title_text": "Evaluating the impact of homoeopathy in managing the morbidity associated with grade III and IV lower limb lymphoedema in adults with lymphatic filariasis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:09Z",
  "url": "https://research.draconitic.com/paper/1h2asw9zhfvpn",
  "venue": "Frontiers in Parasitology",
  "versions": []
}