{
  "abstract": "Background Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a clonal mature B-cell neoplasm with rare extranodal organ renal involvement. Objectives To summarize the clinical and pathological characteristics of biopsy-confirmed CLL/SLL-associated renal lesions and evaluate the efficacy of targeted combination therapy. Design Retrospective multicenter observational study. Methods Eleven patients with CLL/SLL-associated nephropathy were enrolled from January 2017 to October 2024 across three Chinese centers. As of December 31, 2025, data were collected through electronic medical records and telephone follow-up. Results The median age was 58 (range 40–72) years. Among tested patients, 88.9% (8/9) exhibited IGHV mutation and 62.5% (5/8) were CLL-IPI low-risk, and no TP53 mutations were detected. The median time from CLL diagnosis to renal biopsy was 40.7 months (range: 0.2–58 months). Biopsy indictions included proteinuria (90.9%, 10/11), hematuria (54.5%, 6/11), renal dysfunction (54.5%, 6/11), and nephrotic syndrome (9.1%, 1/11). Main pathologies were tumor cell interstitial infiltration (45.5%, 5/11), membranoproliferative glomerulonephritis (27.3%, 3/11), membranous nephropathy (18.2%, 2/11), and C3 glomerulonephritis (9.1%, 1/11). Concomitant monoclonal gammopathy and cryoglobulinemia were observed in 27.3% and 18.2%, respectively. Nine patients received BTKi -based therapy. The best overall response rate (ORR) for CLL/SLL was 100%, with a CR rate of 72.7%. According to KDIGO 2021 guidelines, the renal best ORR was 100%, with a CR rate of 36.4%. Four patients achieved CR in both CLL and renal assessments. As of December 31, 2025, the median follow-up was 70.1 months and median PFS was not reached. Grade ≥3 hematologic toxicities included neutropenia (27.3%) and thrombocytopenia (18.2%). Common non-hematologic adverse events were COVID-19 (27.3%), bleeding (18.2%), and gastrointestinal symptoms (18.2%), all of grade 1-2. Conclusions CLL/SLL with renal involvement is associated with a favorable IGHV-mutated profile. Interstitial infiltration and membranoproliferative glomerulonephritis are the predominant renal pathologies. BTKi-based regimens were associated with favorable hematologic and renal outcomes in this small cohort.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Ling Gao"
    },
    {
      "name": "Minjie Yu"
    },
    {
      "name": "Lixia Sheng"
    },
    {
      "name": "Zhen Wang"
    },
    {
      "name": "Bo Zhang"
    },
    {
      "name": "Xiaoqian Liu"
    },
    {
      "name": "Tonglu Qiu"
    },
    {
      "name": "Wei Zhang"
    },
    {
      "name": "Luomengjia Dai"
    },
    {
      "name": "Ziyuan Zhou"
    },
    {
      "name": "Lei Fan"
    },
    {
      "name": "Jianyong Li"
    },
    {
      "name": "Huayuan Zhu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1h9yzyehrzjq8.bib",
  "cited_by": 0,
  "doi": "10.1177/20406207261501030",
  "fulltext_url": "https://doi.org/10.1177/20406207261501030",
  "id": "1h9yzyehrzjq8",
  "issns": [
    "2040-6215",
    "2040-6207"
  ],
  "landing_url": "https://doi.org/10.1177/20406207261501030",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC633-647.5"
    ],
    [
      "openalex",
      "2716|Chronic Lymphocytic Leukemia Research"
    ]
  ],
  "openalex": "W7223368624",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "SAGE Publishing",
  "ris": "https://research.draconitic.com/paper/1h9yzyehrzjq8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:27Z",
      "native_id": "0278af95adb14e58bb109c0988275bc7",
      "source": "doaj",
      "url": "https://doi.org/10.1177/20406207261501030"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Chronic Lymphocytic Leukemia Research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Clinical characteristics and outcome of CLL/SLL patients with renal involvement in the era of targeted drugs",
  "title_text": "Clinical characteristics and outcome of CLL/SLL patients with renal involvement in the era of targeted drugs",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:20:20Z",
  "url": "https://research.draconitic.com/paper/1h9yzyehrzjq8",
  "venue": "Therapeutic Advances in Hematology",
  "versions": []
}