{
  "abstract": "Methylselenol (CH₃SeH) is not only a key selenium (Se) metabolite but also a potent therapeutic molecule. Chemical tools for stimulus-responsive delivery of CH₃SeH should be crucial for exploring Se-related biomedicine. Nevertheless, the classical 1,6-self-immolation is inefficient in releasing the poorly leaving selenol, and donation platforms for triggerable release of the CH₃SeH remain lacking. Herein, we report the first general responsive platform (Triggered Donation for MethylSelenol, termed TD-MSe) via fast intramolecular amino-activated methylselenocarbamates (t1/2 = 5 s at pH 7.4), enabling the efficient cyclization release of CH₃SeH without electrophilic byproducts. We leverage the caged TD-MSe motifs to successfully create triggered donors that are stable before activation but can liberate CH₃SeH under different stimulus conditions in vitro and in live cells. Additionally, we demonstrate that the tumor-associated oxidoreductase (hNQO1)-triggered CH₃SeH donor was activated in hNQO1-positive HT-29 cells but not in hNQO1-negative cells. Moreover, we can use the CH₃SeH prodrug to selectively kill metastatic cells of hNQO1-overexpressing cancer types, providing a promising therapeutic strategy for difficult-to-treat diseases. We anticipate that the new-release chemistry will be widely applied for developing advanced tools toward smart selenol delivery and therapy.",
  "abstract_shown": true,
  "affiliations": [
    "College of Chemical Engineering and Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, China.",
    "Tianjin Key Laboratory On Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China.",
    "National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center For New Organic Matter, Nankai University, Tianjin, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wenfang Liang"
    },
    {
      "affs": [
        1
      ],
      "name": "Liyue Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinran Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Hao Xing"
    },
    {
      "affs": [
        1
      ],
      "name": "Lu Sun",
      "orcid": "0000-0002-1946-0766"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhen Xi",
      "orcid": "0000-0002-3332-5413"
    },
    {
      "affs": [
        0
      ],
      "name": "Long Yi",
      "orcid": "0000-0001-5629-7446"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1hr32n345jc4w.bib",
  "cited_by": 0,
  "doi": "10.1002/advs.78356",
  "fulltext_url": "https://europepmc.org/articles/PMC13677048",
  "id": "1hr32n345jc4w",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://europepmc.org/article/MED/42893486",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3005|Organoselenium and organotellurium chemistry"
    ]
  ],
  "openalex": "W7222906116",
  "pdf_url": "https://europepmc.org/articles/PMC13677048?pdf=render",
  "pmcid": "PMC13677048",
  "pmid": "42893486",
  "published": "2026-10-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1hr32n345jc4w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42893486",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42893486"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3005|Organoselenium and organotellurium chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Harnessing Methylselenol (CH₃SeH): A Highly Effective Platform for Stimuli-Responsive Delivery With Therapeutic Potential.",
  "title_text": "Harnessing Methylselenol (CH₃SeH): A Highly Effective Platform for Stimuli-Responsive Delivery With Therapeutic Potential.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/1hr32n345jc4w",
  "venue": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
  "versions": []
}