{
  "abstract": "Visceral disseminated varicella-zoster virus infection (VD-VZV) is a rare but life-threatening condition, and treatment-response monitoring has not yet been established. We report a case of a 47-year-old woman with systemic lupus erythematosus who developed primary varicella complicated by VD-VZV during prednisolone and mycophenolate mofetil therapy. She presented with a generalized vesicular rash, dyspnea, severe epigastric pain, pneumonia, and acute hepatitis with negative VZV IgM/IgG. Intravenous acyclovir was initiated and escalated, resulting in a clinical improvement. Serum VZV DNA quantified by droplet digital PCR peaked on day 4 (3.1×106 copies/mL) and declined with recovery, suggesting that serial serum VZV DNA monitoring may be useful for assessing the disease activity and treatment response in such patients.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Takuji Omoto"
    },
    {
      "name": "Hiroki Kitagawa"
    },
    {
      "name": "Keitaro Omori"
    },
    {
      "name": "Kayoko Tadera"
    },
    {
      "name": "Toshihito Nomura"
    },
    {
      "name": "Norifumi Shigemoto"
    },
    {
      "name": "Shintaro Hirata"
    },
    {
      "name": "Hiroki Ohge"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1j1g6t5hk0v7g.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7804-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7804-26/_article",
  "id": "1j1g6t5hk0v7g",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7804-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2713|Herpesvirus Infections and Treatments"
    ]
  ],
  "openalex": "W7203666505",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7804-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1j1g6t5hk0v7g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7804-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7804-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Herpesvirus Infections and Treatments",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Longitudinal Evaluation of Serum Varicella-zoster Virus Viral Load in a Woman with Systemic Lupus Erythematosus Complicated by a Visceral Disseminated Varicella-zoster Virus Infection: A Case Report",
  "title_text": "Longitudinal Evaluation of Serum Varicella-zoster Virus Viral Load in a Woman with Systemic Lupus Erythematosus Complicated by a Visceral Disseminated Varicella-zoster Virus Infection: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/1j1g6t5hk0v7g",
  "venue": "Internal Medicine",
  "versions": []
}