{
  "abstract": "A versatile method for the preparation of synthetically valuable β2-homologated amino acid esters from simple α-amino acid esters is described. Inspired by pyridoxal 5′-phosphate-dependent aminomutase enzymes, the described strategy exploits a straightforward protocol for substrate activation, alkylation, and migration leveraging a bio-inspired 3-exo-trig radical cascade. This approach enables a novel homologative strategy towards β-amino acids via methylene insertion into the Cα–N bond of α-amino acids. A broad substrate scope is demonstrated, and key activator electronic factors are elucidated through experimental and computational mechanistic studies. By engaging α-amino acids directly, the method provides unique access to β2-homologated amino acids.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry",
    "Stony Brook University",
    "Institute of Chemical Biology and Drug Discovery"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ayah W. Fidama"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Vincent Huang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yetong Lin"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jaclyn N. Mauro"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ethan T. A. Raffman"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jialin Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jeffrey M. Lipshultz",
      "orcid": "0000-0002-1384-9850"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1j83yhv42sk11.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009423/v1",
  "fulltext_url": null,
  "id": "1j83yhv42sk11",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009423/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7214240234",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009423/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-24",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/1j83yhv42sk11.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009423",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009423/v2"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Aminomutase-Inspired Methylene Insertion for α-to-β Homologative Transposition of Amino Acids",
  "title_text": "Aminomutase-Inspired Methylene Insertion for α-to-β Homologative Transposition of Amino Acids",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/1j83yhv42sk11",
  "venue": "ChemRxiv",
  "versions": []
}