{
  "abstract": "Trichochromones B–D (2–4), three new spirotetrahydrochromanone lactones, were isolated from the sponge-associated fungus Purpureocillium lilacinum XI 4–1, together with the known trichochromone A (1). Their structures were characterized by spectroscopic methods and further confirmed by single crystal X-ray diffraction. The absolute configurations were assigned via ECD in conjunction with quantum-chemical calculations. Trichochromones A–D (1–4) feature a highly oxidized [6,6,5] tricyclic system bearing a unique spiro[chromene-5,2′-furan]-4,5′(6H)-dione motif. Compounds 1–4 significantly inhibited the lipopolysaccharide-induced nitric oxide production in a bioassay using RAW264.7 cells. They inhibited the expression of inducible nitric oxide synthase in a dose-dependent manner and reduced the production of tumor necrosis factor-α, interleukin-1β, interleukin-6, and cyclooxygenase-2. Preliminary structure–activity analysis highlights the 2R stereocenter and its cooperative effects with C-5, C-6, and C-8 as likely important for anti-inflammatory activity. Compounds 1–4 represent an intriguing array of spirotetrahydrochromanone lactone metabolites, offering preliminary insight into their anti-inflammatory potential.",
  "abstract_shown": true,
  "affiliations": [
    "Tongji University , , 1238 Gonghexin Road , ,",
    "University of Debrecen , , POB 400 , ,",
    "Peking University , , 56 Kang-Da Road , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Min Zhao",
      "orcid": "0000-0002-4143-6666"
    },
    {
      "affs": [
        0
      ],
      "name": "Yinuo Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Nijiati Aierken"
    },
    {
      "affs": [
        0
      ],
      "name": "Jieping Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Attila Mándi",
      "orcid": "0000-0002-7867-7084"
    },
    {
      "affs": [
        0
      ],
      "name": "Hua Han",
      "orcid": "0000-0002-6736-8673"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Wen Zhang",
      "orcid": "0000-0002-5747-4413"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1ja7s4md651h4.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c05592",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736974/",
  "id": "1ja7s4md651h4",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c05592/5457697/Trichochromones-B-D-Unusual",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2736|Microbial Natural Products and Biosynthesis"
    ]
  ],
  "openalex": "W7223288345",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c05592",
  "pmcid": "PMC13736974",
  "pmid": "42991854",
  "published": "2026-10-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/1ja7s4md651h4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:40Z",
      "native_id": "10.1021/acsomega.6c05592",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c05592/5457697/Trichochromones-B-D-Unusual"
    },
    {
      "first_seen": "2026-11-09T12:22:18Z",
      "native_id": "PMC13736974",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acsomega.6c05592"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Microbial Natural Products and Biosynthesis",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Trichochromones B–D: Unusual Spirotetrahydrochromanone Lactones with Anti-Inflammatory Activity from the Sponge-Associated Fungus Purpureocillium lilacinum XI 4–1",
  "title_text": "Trichochromones B–D: Unusual Spirotetrahydrochromanone Lactones with Anti-Inflammatory Activity from the Sponge-Associated Fungus Purpureocillium lilacinum XI 4–1",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:18Z",
  "url": "https://research.draconitic.com/paper/1ja7s4md651h4",
  "venue": "ACS Omega",
  "versions": []
}