{
  "abstract": "Objectives This study aimed to assess the positivity rate, disease burden, and complications of rotavirus gastroenteritis (RVGE) among Chinese children under 14 years of age presenting with acute gastroenteritis (AGE).Methods A multicentre, observational, and retrospective study was conducted at 11 centres across China (July 2013 - June 2023). Data on RVGE prevalence, direct medical costs, and complications were analyzed, with projections of direct economic burden for 2025 - 2034.Results Out of 505,987 AGE visits, the rotavirus positivity rate was 15.70%, peaked at 26.41% in the 12-month period from July 2016 to June 2017, and the annual positivity rate declined by 19.63% between 2017 and 2023. Among 7,113 RVGE cases, 28.57% of inpatients had recorded complications, and the estimated rate of recorded complications among all RVGE patients was 8.29%, most commonly recorded complications being myocardial damage, dehydration, respiratory infection, convulsion, and metabolic acidosis. The median cost of RVGE was CNY 272.80 (USD 40.68) for outpatients and CNY 5336.60 (USD 795.69) for inpatients, respectively. Projected economic burden is estimated to decrease from CNY 8.55 billion (USD 1.21 billion) in 2025 to CNY 3.96 billion (USD 559 million) in 2034.Conclusions RVGE was associated with high complication rates. The decrease in rotavirus prevalence since 2018, highlighting the public health value of a series of preventive measures during this period, including vaccination.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, 38th Xueyuan Road, Haidian District, Beijing, 100191, People’s Republic of China",
    "Department of Clinical Laboratory, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing Medical University, Chongqing, 401147, People’s Republic of China",
    "Value & Implementation, MSD China, Shanghai, 200030, People’s Republic of China",
    "Department of Science Education and Digital Intelligence, Xiaoshan Center for Disease Control and Prevention, Hangzhou, 311201, People’s Republic of China",
    "Department of Clinical Laboratory, Guiyang Maternal and Child Health Hospital, Guiyang, 550003, People’s Republic of China",
    "Department of Clinical Laboratory, Xi'an Children's Hospital, Xi'an, 710003, People's Republic of China",
    "Department of Pediatric Internal Medicine, Maternal and Child Health Care Hospital of the Inner Mongolia Autonomous Region, Hohhot, 010020, People’s Republic of China",
    "Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, 100191, People’s Republic of China",
    "Department of Nutrition, Aerospace Center Hospital, Beijing, 100049, People’s Republic of China",
    "Department of Clinical Laboratory, Capital Medical University, Beijing Tongren Hospital, Beijing, 100005, People’s Republic of China",
    "Department of Clinical Laboratory, Children's Hospital of Xinjang Uygur Autonomous Region, Uygur, 830054, People’s Republic of China",
    "Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, People’s Republic of China",
    "Department of Clinical Laboratory, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, People's Republic of China",
    "Department of Emergency Pediatrics, Linyi Maternal and Child Health Care Hospital, Linyi, 276016, People's Republic of China",
    "Department of Clinical Laboratory, Hunan Children's Hospital, Changsha, 410007, People's Republic of China",
    "Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, 100049, People’s Republic of China",
    "School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, People’s Republic of China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 27,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shanshan Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Chunli Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Yongyu Su"
    },
    {
      "affs": [
        3
      ],
      "name": "Xuewei Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Lu Liang"
    },
    {
      "affs": [
        5
      ],
      "name": "Lin Song"
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    {
      "affs": [
        6
      ],
      "name": "Yumin Wang"
    },
    {
      "affs": [
        7
      ],
      "name": "Juan Du"
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    {
      "affs": [
        8
      ],
      "name": "Meiyan Xu"
    },
    {
      "affs": [
        9
      ],
      "name": "Mingze Su"
    },
    {
      "affs": [
        10
      ],
      "name": "Xinjie Shan"
    },
    {
      "affs": [
        11
      ],
      "name": "Yuting Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Han Yang"
    },
    {
      "affs": [
        12
      ],
      "name": "Yaoyao Zhao"
    },
    {
      "affs": [
        13
      ],
      "name": "Dongdong Yang"
    },
    {
      "affs": [
        14
      ],
      "name": "Zhichun Ye"
    },
    {
      "affs": [
        1
      ],
      "name": "Yan Su"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuanmei Feng"
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    {
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        4
      ],
      "name": "Li Cheng"
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    {
      "affs": [
        5
      ],
      "name": "Jianfei Shi"
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    {
      "affs": [
        6
      ],
      "name": "Huifang Song"
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    {
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        15
      ],
      "name": "Xuekai Liu"
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    {
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        12
      ],
      "name": "Xingwen Hu"
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    {
      "affs": [
        13
      ],
      "name": "Jiasheng Zang"
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    {
      "affs": [
        14
      ],
      "name": "Zhengqiu Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Fuqiang Cui"
    },
    {
      "affs": [
        16
      ],
      "name": "Qingbin Lu"
    }
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  "doi": "10.1080/22221751.2026.2751700",
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  "published": "2026-11-05",
  "publisher": "Taylor & Francis Group",
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  "title": "Disease burden of rotavirus infection and its complications among children under 14 years old with acute gastroenteritis in China: a multicentre and retrospective study",
  "title_text": "Disease burden of rotavirus infection and its complications among children under 14 years old with acute gastroenteritis in China: a multicentre and retrospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T14:20:42Z",
  "url": "https://research.draconitic.com/paper/1jdwchdzg8epz",
  "venue": "Emerging Microbes and Infections",
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