{
  "abstract": "Background\n\nIschemic stroke (IS), a leading global health problem, is caused by interrupted blood flow in the brain, often due to clotting or artery constriction. Long non-coding RNAs (lncRNAs), particularly HOX transcript antisense intergenic RNA (HOTAIR), are pivotal in stroke pathophysiology.Aim\n\nThis study focused on the expression levels of HOTAIR lncRNA in ischemic stroke patients.Methods and materials\n\nThis comparative cross-sectional study with 100 participants: 50 IS patients and 50 patients without IS serving as controls. The study gathered demographic data, disease specifics, and medication history. Blood samples were analyzed for HOTAIR lncRNA expression levels.Results\n\nThis study showed significantly higher expression levels of HOTAIR lncRNA among IS patients compared to the control group (5.73 ± 0.75 vs. 2.35 ± 0.29; P < 0.001), with an average increase of 3.19 units compared to the control group (P < 0.001) after adjusting the independent variables. Additionally, participants with hypertension had an average increase of 0.36 units in of HOTAIR lncRNA expression compared to the control group (P = 0.041).Conclusion\n\nOur study found that HOTAIR lncRNA levels are significantly higher in IS patients and may be associated with a history of hypertension. diseases. This suggests that HOTAIR lncRNA could be a useful biomarker for stroke and related conditions.",
  "abstract_shown": true,
  "affiliations": [
    "Neuroscience Research Centre, Neurology Department, Poursina Hospital, Guilan University of Medical Sciences, Guilan, Iran.",
    "Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.",
    "Neuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.",
    "Faculty of Medicine, Guilan University of Medical Science, Rasht, Iran.",
    "Faculty of Medicine, Guilan University of Medical Science, Rasht, Iran. khoshdoozsara@gmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alia Saberi"
    },
    {
      "affs": [
        0
      ],
      "name": "Niloufar Nabavi"
    },
    {
      "affs": [
        0
      ],
      "name": "Amirreza Ghayeghran"
    },
    {
      "affs": [
        1
      ],
      "name": "Zivar Salehi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaser Moaddabi"
    },
    {
      "affs": [
        2
      ],
      "name": "Mohammad Ebrahim Ghaffari"
    },
    {
      "affs": [
        3
      ],
      "name": "Haniyeh Haghanipor"
    },
    {
      "affs": [
        4
      ],
      "name": "Sara Khoshdooz"
    },
    {
      "affs": [
        3
      ],
      "name": "Ali Bonyad"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1jyz0m9ymm4q2.bib",
  "cited_by": 0,
  "doi": "10.1186/s13104-025-07487-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13685211",
  "id": "1jyz0m9ymm4q2",
  "issns": [
    "1756-0500"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902418",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q1-390"
    ],
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "1306|Cancer-related molecular mechanisms research"
    ]
  ],
  "openalex": "W7170964842",
  "pdf_url": "https://europepmc.org/articles/PMC13685211?pdf=render",
  "pmcid": "PMC13685211",
  "pmid": "42902418",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1jyz0m9ymm4q2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42902418",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902418"
    },
    {
      "first_seen": "2026-10-30T13:45:38Z",
      "native_id": "c8ba2afcca364c28907f5c0da667d854",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s13104-025-07487-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer-related molecular mechanisms research",
      "subfield": "oncology"
    }
  ],
  "title": "Investigating long non-coding RNA (lncRNA) HOTAIR expression changes in ischemic stroke patients.",
  "title_text": "Investigating long non-coding RNA (lncRNA) HOTAIR expression changes in ischemic stroke patients.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:38Z",
  "url": "https://research.draconitic.com/paper/1jyz0m9ymm4q2",
  "venue": "BMC research notes",
  "versions": []
}