{
  "abstract": "Background/Objectives: Maxillary sinus floor augmentation (MSFA) via the lateral approach is a well-established procedure for prosthetic rehabilitation of atrophic posterior maxillae. However, late complications are often nonspecific, with an incompletely understood aetiology. We evaluated patients with atypical late complications post-MSFA with bovine xenohybrid bone substitute NaturesQue SemOss B (BEGO GmbH, Bremen, Germany), describing their presentation, management, and outcomes. Methods: This retrospective, complication-selected clinical case series examined 47 patients who underwent lateral window MSFA with this graft from September 2020 to March 2023 in a single university department. Twelve complication cases were identified during the study period. Atypical late complications were defined as graft-associated clinical and/or radiological adverse outcomes, excluding peri-implantitis, that first manifested > 6 mo postoperatively. Baseline characteristics, perioperative findings, conservative and surgical management (including graft removal and reaugmentation), histology, and follow-up were assessed. Results: Twelve complication cases were identified among 47 patients treated during the study period. Seven experienced implant loss; seven, partial or complete lack of graft osseointegration; six, pain; and seven, signs of sinus infection. Histological analysis (6/12) revealed lymphocytes, plasma cells, and fibroblastic changes without detectable macrophages. No intraoperative complications were observed. Conclusions: Atypical late complications affected 25.5% of the patients. Despite comprehensive clinical, radiological, and histological assessments, the aetiology remained unclear, and the findings did not indicate a peri-implantitis-type infection; we hypothesised impaired early phase wound healing These patients were amenable to repeat augmentation post-non-osseointegrated graft removal, although larger studies are required.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, A-3500 Krems-Stein, Austria.",
    "Clinical Application of Artificial Intelligence in Dentistry (CAAID) Group, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, A-3500 Krems-Stein, Austria.",
    "Dental Practice, 9490 Vaduz, Liechtenstein.",
    "Medical Image Analysis & Artificial Intelligence (MIAAI) Group, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, 3500 Krems An Der Donau, Austria."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Patrick Bandura",
      "orcid": "0000-0002-6808-6563"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Christian Philipp Schnell"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Claas Willem Molsen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Anna Sophia Bandura"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pascal Grün",
      "orcid": "0000-0003-2639-0409"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Marius Meier",
      "orcid": "0009-0003-1410-6543"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maximilian Jung",
      "orcid": "0009-0006-0606-4541"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Flora Turhani",
      "orcid": "0009-0009-2217-446X"
    },
    {
      "affs": [
        3
      ],
      "name": "Sebastian Fitzek",
      "orcid": "0000-0001-6454-7820"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Dritan Turhani",
      "orcid": "0000-0002-7311-3191"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1krnz7gsfk6j1.bib",
  "cited_by": 0,
  "doi": "10.3390/diagnostics16193098",
  "fulltext_url": "https://europepmc.org/articles/PMC13664600",
  "id": "1krnz7gsfk6j1",
  "issns": [
    "2075-4418"
  ],
  "landing_url": "https://europepmc.org/article/MED/42882252",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3504|Dental Implant Techniques and Outcomes"
    ]
  ],
  "openalex": "W7214240529",
  "pdf_url": "https://europepmc.org/articles/PMC13664600?pdf=render",
  "pmcid": "PMC13664600",
  "pmid": "42882252",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1krnz7gsfk6j1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42882252",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42882252"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Delayed Complications After Maxillary Sinus Floor Augmentation with a Bovine Xenohybrid Bone Graft: A Retrospective Clinical Case Series.",
  "title_text": "Delayed Complications After Maxillary Sinus Floor Augmentation with a Bovine Xenohybrid Bone Graft: A Retrospective Clinical Case Series.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/1krnz7gsfk6j1",
  "venue": "Diagnostics (Basel, Switzerland)",
  "versions": []
}