{
  "abstract": "SUMMARY: Tartary buckwheat (Fagopyrum tataricum) is renowned for its adaptability to complex growing conditions and stress tolerance. However, soil‐borne necrotrophic pathogens such as Rhizoctonia solani frequently cause devastating diseases that severely compromise its yield and quality. In this study, through a genome‐wide association study (GWAS), we identified a carboxylesterase gene, FtCES18, and demonstrated that it acts as a core positive regulator of disease resistance in Tartary buckwheat. Overexpression of FtCES18 significantly enhanced plant resistance, whereas virus‐induced gene silencing (VIGS) led to a highly susceptible phenotype. Further analyses revealed that FtCES18 efficiently catalyzes the hydrolysis of methyl jasmonate (MeJA) into free jasmonic acid (JA), which initiates downstream JA‐Ile signaling and rapidly promotes endogenous jasmonate accumulation upon pathogen infection. This JA signaling cascade reprograms host flavonoid metabolism, promoting the substantial accumulation of downstream defensive flavonoids (such as rutin and quercetin). Furthermore, we found that the transcription factor FtMYB32 directly binds to the MBS cis‐element in the FtCES18 promoter to activate its expression. Notably, evolutionary analysis revealed a domestication‐associated C‐terminal truncation in the cultivated FtMYB32 that impairs its transactivation capacity, explaining the compromised basal resistance in cultivated accessions compared to their wild ancestors. Crucially, a natural single‐nucleotide polymorphism (SNP) in the FtMYB32 promoter defines a superior haplotype (hapC) conferring enhanced basal transcriptional activity. This natural variation in promoter activity controls the expression abundance of the FtMYB32‐FtCES18 module via a “dosage fine‐tuning” effect, which is subsequently amplified by the downstream metabolic cascade, ultimately contributing to the natural variation in disease resistance among different Tartary buckwheat accessions. This study provides valuable genetic resources and a theoretical basis for breeding novel Tartary buckwheat varieties with high disease resistance.",
  "abstract_shown": true,
  "affiliations": [
    "Sanya Nan Fan Research Institute of Chinese Academy of Agricultural Sciences Sanya Hainan 572024 China",
    "Hainan Seed Industry Laboratory Sanya 572024 China",
    "State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China",
    "College of Agriculture Yangtze University Jingzhou Hubei 434023 China",
    "School of Life and Health Sciences Hunan University of Science and Technology Xiangtan Hunan 411201 China",
    "Alliance of Bioversity International and CIAT New Delhi India",
    "School of Life Sciences Royal Global University Guwahati India",
    "Skolkovo Institute of Science and Technology Moscow Russia",
    "Vavilov Institute of General Genetics Russian Academy of Science Moscow Russia",
    "Institute of Economic Crops Henan Academy of Agricultural Sciences Zhengzhou 450003 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Yuanyuan Chen",
      "orcid": "0009-0002-5983-0204"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yang Liu",
      "orcid": "0000-0001-6714-8569"
    },
    {
      "affs": [
        4
      ],
      "name": "Xixu Peng"
    },
    {
      "affs": [
        4
      ],
      "name": "Haihua Wang",
      "orcid": "0000-0001-8838-9214"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhengwu Fang"
    },
    {
      "affs": [
        5
      ],
      "name": "Jai Chand Rana"
    },
    {
      "affs": [
        6
      ],
      "name": "Nikhil Chrungoo",
      "orcid": "0000-0002-7706-9300"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Maria D Logachev"
    },
    {
      "affs": [
        1,
        9
      ],
      "name": "Chaonan Guan",
      "orcid": "0000-0001-6542-2229"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Meiliang Zhou",
      "orcid": "0000-0001-5175-3684"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1kxr2xxgbxfch.bib",
  "cited_by": 0,
  "doi": "10.1111/tpj.71176",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698632/",
  "id": "1kxr2xxgbxfch",
  "issns": [
    "0960-7412",
    "1365-313X"
  ],
  "landing_url": "https://doi.org/10.1111/tpj.71176",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "1110|Plant Disease Resistance and Genetics"
    ]
  ],
  "openalex": "W7223676900",
  "pdf_url": "https://europepmc.org/articles/PMC13698632?pdf=render",
  "pmcid": "PMC13698632",
  "pmid": "42929225",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1kxr2xxgbxfch.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:29Z",
      "native_id": "PMC13698632",
      "source": "pmc",
      "url": "https://doi.org/10.1111/tpj.71176"
    },
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929225",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929225"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Disease Resistance and Genetics",
      "subfield": "plant-biology"
    }
  ],
  "title": "Natural variation in a FtMYB32 ‐ FtCES18 module drives Rhizoctonia solani resistance by reprogramming jasmonate and flavonoid metabolism in Tartary buckwheat",
  "title_text": "Natural variation in a FtMYB32 ‐ FtCES18 module drives Rhizoctonia solani resistance by reprogramming jasmonate and flavonoid metabolism in Tartary buckwheat",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:35:28Z",
  "url": "https://research.draconitic.com/paper/1kxr2xxgbxfch",
  "venue": "The Plant Journal",
  "versions": []
}