{
  "abstract": "Autonomous cortisol secretion (ACS) from adrenal adenomas increases cardiometabolic risk. Visceral adiposity is a hallmark of ACS. We characterized ACS-associated visceral adiposity using multi-omics profiling of periadrenal adipose tissue and plasma. ACS exhibited higher visceral-to-subcutaneous fat ratio (VSR), adipocyte hypertrophy, and inflammation-related pathway enrichment than non-functioning adrenal tumors. RNA-seq deconvolution and immunohistochemistry indicated increased macrophage infiltration. Plasma steroid metabolomics identified 11-deoxycorticosterone (11-DOC), a mineralocorticoid metabolite, as positively associated with VSR in premenopausal ACS women independent of cortisol. The 11-DOC-associated gene module correlated with inflammation-related pathways, notably macrophage activation. Lipidomics identified ceramides as ACS discriminators, with Cer(d18:1/16:0) most strongly associated with inflammation- and lipid metabolism-related pathways. Mendelian randomization showed genetically predicted plasma Cer(d18:1/16:0) was positively associated with trunk fat mass. These findings identify circulating 11-DOC and adipose ceramide accumulation as molecular features associated with adipose inflammation and visceral adiposity in ACS, providing hypothesis-generating insights that require functional validation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "Hiroshi Nakao"
    },
    {
      "name": "Maki Yokomoto-Umakoshi",
      "orcid": "0000-0003-0934-9148"
    },
    {
      "name": "Masamichi Fujita"
    },
    {
      "name": "Kohta Nakatani"
    },
    {
      "name": "Yuya Kitamura"
    },
    {
      "name": "Ryo Ogasawara"
    },
    {
      "name": "Hiroki Kaneko"
    },
    {
      "name": "Norifusa Iwahashi"
    },
    {
      "name": "Yui Nakano"
    },
    {
      "name": "Tazuru Fukumoto"
    },
    {
      "name": "Tatsuki Ogasawara"
    },
    {
      "name": "Hiroki Takayanagi"
    },
    {
      "name": "Takashi Matsumoto"
    },
    {
      "name": "Yoshihiro Izumi"
    },
    {
      "name": "Masatoshi Eto"
    },
    {
      "name": "Takeshi Bamba"
    },
    {
      "name": "Hironobu Umakoshi"
    },
    {
      "name": "Yoshihiro Ogawa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1m070ahbnfg3m.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117776",
  "fulltext_url": "https://europepmc.org/articles/PMC13677310",
  "id": "1m070ahbnfg3m",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03157-3",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Health sciences"
    ],
    [
      "openalex",
      "2713|Adipokines, Inflammation, and Metabolic Diseases"
    ]
  ],
  "openalex": "W7221059302",
  "pdf_url": "https://europepmc.org/articles/PMC13677310?pdf=render",
  "pmcid": "PMC13677310",
  "pmid": "42898132",
  "published": "2026-10-08",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/1m070ahbnfg3m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117776",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03157-3"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117776",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226031573"
    },
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898132",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898132"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Adipokines, Inflammation, and Metabolic Diseases",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Multi-omics profiling reveals molecular features of visceral adiposity in autonomous cortisol secretion",
  "title_text": "Multi-omics profiling reveals molecular features of visceral adiposity in autonomous cortisol secretion",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/1m070ahbnfg3m",
  "venue": "iScience",
  "versions": []
}