{
  "abstract": "Molecular profiling is central to pediatric precision oncology, yet only 15-20% of patients benefit from biology-guided treatments. This limitation underscores the urgent need for functional precision medicine, which interrogates therapeutic vulnerabilities using patient-derived models. Despite hurdles in establishing these models, such as limited biopsy material and technical screening barriers, recent advances in tumoroids, patient-derived xenografts and high-throughput platforms offer an unprecedented opportunity to bridge the translational gap. In this review, we describe the evolution of patient-derived models of ped iatric brain cancers, their current strengths and weaknesses and the technological innovations redefining the field. Together, these insights provide a road map for integrating functional data into clinical decision-making, ultimately aiming to 'cure more and heal better' children with brain tumors.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Julie Lafont"
    },
    {
      "name": "Mathilde Kerhervé"
    },
    {
      "name": "Nicolas André"
    },
    {
      "name": "Marion Le Grand"
    },
    {
      "name": "Eddy Pasquier"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1mf5yvypz643m.bib",
  "cited_by": 0,
  "doi": "10.1016/j.trecan.2026.06.001",
  "fulltext_url": null,
  "id": "1mf5yvypz643m",
  "issns": [
    "2405-8033"
  ],
  "landing_url": "https://hal.science/hal-05850736v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7166120919",
  "pdf_url": "https://hal.science/hal-05850736/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/1mf5yvypz643m.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:20:53Z",
      "native_id": "hal-05850736",
      "source": "hal",
      "url": "https://hal.science/hal-05850736v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Glioma Diagnosis and Treatment",
      "subfield": "human-genetics"
    }
  ],
  "title": "Precision neuro-oncology for children: Time to gear up!",
  "title_text": "Precision neuro-oncology for children: Time to gear up!",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:12Z",
  "url": "https://research.draconitic.com/paper/1mf5yvypz643m",
  "venue": "Trends in Cancer",
  "versions": []
}