{
  "abstract": "This randomized controlled trial aims to investigate the effects of resistance training (RT) volume (high vs. low) and non-exercise group on depressive symptoms, remission rates, adherence and the psychological and neurobiological mechanisms underlying these effects in patients with major depressive disorder (MDD). A total of 150 adults (18-59 years) diagnosed with MDD will be randomized into three groups: high-volume RT (HV, n=50; 4 sets of 10-12 repetition maximum [RM]), low-volume RT (LV, n=50; 2 sets of 10-12 RM), and a non-exercise control group (CG, n=50). Participants in the intervention groups will train three non-consecutive days per week for 8 weeks. The primary outcome, depressive symptoms, will be assessed by a psychiatrist using the Montgomery-Åsberg Depression Rating Scale. Secondary outcomes will include potential psychological mechanisms (perceived self-efficacy, affective responses to exercise, and well-being), assessed at baseline, post-intervention, and at the 3-month follow-up, and neurobiological mechanisms assessed by inflammatory and metabolic biomarkers related to MDD pathophysiology, including TNF-α, IL-6, IL-10, IL-1β, CRP, IGF-1, BDNF, insulin, glucose, and cortisol, measured before and after the intervention. Tertiary outcomes will include dietary intake and ultra-processed food consumption (24-hour dietary recall), body composition (DXA), muscular strength, and sleep quality. Intervention efficacy will be analyzed using intention-to-treat linear mixed-effects models. The findings may contribute to more effective, personalized, and sustainable RT prescriptions that improve adherence and complement conventional treatments for MDD.Clinical trials registration\n\nhttps://ensaiosclinicos.gov.br/rg/, identifier RBR-9tn4ncp.",
  "abstract_shown": true,
  "affiliations": [
    "Immunometabolism of Skeletal Muscle and Exercise Research Group and Strength Training and Exercise Research Group (GEDEF), Department of Physical Education, São Paulo State University (UNESP), School of Technology and Science (FCT), Presidente Prudente, Brazil.",
    "Graduate Program in Movement Science - Interunits, São Paulo State University (UNESP), Presidente Prudente, Brazil.",
    "Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.",
    "Department of Biochemistry, Federal University of São Paulo, São Paulo, São Paulo, Brazil.",
    "Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.",
    "Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States.",
    "Clinical Division of Social Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.",
    "Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.",
    "Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.",
    "Division of Psychology and Mental Health, Manchester Academic Health Science Centre, Manchester, United Kingdom.",
    "University of Manchester, Manchester, United Kingdom.",
    "Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, Berlin, Germany.",
    "School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.",
    "Facultad de Deportes, Universidad Autónoma de Baja California, Ensenada, Mexico.",
    "Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia.",
    "Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, VIC, Australia.",
    "Graduate Program of Movement and Rehabilitation Sciences, Universidade Federal de Santa Maria, Santa Maria, Brazil.",
    "Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago, Chile.",
    "Graduate Program Human Development and Technologies, São Paulo State University (UNESP), Rio Claro, Brazil."
  ],
  "article_type": "methods article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Giovanni Henrique Quizzini"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jessenia Marise Sales Campos"
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    {
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        1
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      "name": "Thaís Aparecida Medeiros Amorim"
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      "name": "Marcelo Augusto Alves Dos Santos"
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      "name": "André Felipe Oliveira da Cruz"
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    {
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      "name": "Mateus Sanches Jokura"
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    {
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      ],
      "name": "Matheus Augusto Martins Correia"
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    {
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      ],
      "name": "Julia Elis Baraldo"
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      "name": "Marina Trombetta-Lima"
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      "name": "Camila Nascimento"
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      "name": "Andrea Deslandes"
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      "name": "André Oliveira Werneck"
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        11
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      "name": "Brendon Stubbs"
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    {
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      "name": "Hashim Islam"
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    {
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      ],
      "name": "Alberto Jiménez-Maldonado"
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        17
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      "name": "Felipe Barreto Schuch"
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    {
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        18
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      "name": "Lucas Melo Neves"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Fabrício Eduardo Rossi"
    }
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  "bibtex": "https://research.draconitic.com/paper/1mgzfpkr7bgb6.bib",
  "cited_by": 0,
  "doi": "10.3389/fphys.2026.1943543",
  "fulltext_url": "https://europepmc.org/articles/PMC13713303",
  "id": "1mgzfpkr7bgb6",
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  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
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  "native_subjects": [
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  "pdf_url": "https://europepmc.org/articles/PMC13713303?pdf=render",
  "pmcid": "PMC13713303",
  "pmid": "42952510",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/1mgzfpkr7bgb6.ris",
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  "subjects": [
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  ],
  "title": "Resistance training volume for major depressive disorder: the MoveMind randomized controlled trial protocol.",
  "title_text": "Resistance training volume for major depressive disorder: the MoveMind randomized controlled trial protocol.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:00Z",
  "url": "https://research.draconitic.com/paper/1mgzfpkr7bgb6",
  "venue": "Frontiers in physiology",
  "versions": []
}