{
  "abstract": "Kidney-targeted gene transfer is progressing toward two distinct clinical applications: correcting molecular defects or modifying disease pathways in native kidneys and modifying donor kidneys before allotransplantation to reduce ischemia-reperfusion injury or rejection. These applications share a delivery challenge but differ in their target cells, therapeutic mechanisms, required duration and acceptable systemic exposure. Advances in renal delivery have produced disease benefit in selected animal models, while ex vivo perfusion offers a controlled opportunity to expose and assess a graft before implantation. Neither renal vector detection nor reporter expression alone establishes therapeutic efficacy. This review evaluates the evidence through four linked layers: vector distribution, cell-resolved delivery or expression, therapeutic target engagement and functional benefit. It compares candidate strategies according to indication and duration, distinguishes capsid tropism from promoter-mediated expression bias and separates demonstrated outcomes from mechanistic proposals. For donor-kidney engineering, limited treatment time, uneven intrarenal delivery, perfusion injury and delayed vector release after reperfusion remain central constraints. Translation will require indication-specific dose-response studies, human-relevant delivery assessment and surveillance extending beyond early benefit or transient immune silencing. Progress therefore depends on a coherent therapeutic configuration, rather than a universal kidney vector.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.",
    "Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan 430030, China.",
    "National Health Commission Key Laboratory of Organ Transplantation, Wuhan 430030, China.",
    "Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China.",
    "Hubei Provincial Clinical Research Center for Organ Transplantation, Wuhan 430030, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yongfa Lei"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Ruying Zheng"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Daqiang Zhao",
      "orcid": "0000-0003-2582-0112"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1mjcg1p6y7hze.bib",
  "cited_by": 0,
  "doi": "10.3390/genes17101270",
  "fulltext_url": "https://europepmc.org/articles/PMC13704283",
  "id": "1mjcg1p6y7hze",
  "issns": [
    "2073-4425"
  ],
  "landing_url": "https://europepmc.org/article/MED/42938385",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Virus-based gene therapy research"
    ]
  ],
  "openalex": "W7221641253",
  "pdf_url": "https://europepmc.org/articles/PMC13704283?pdf=render",
  "pmcid": "PMC13704283",
  "pmid": "42938385",
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1mjcg1p6y7hze.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42938385",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42938385"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Virus-based gene therapy research",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Kidney-Targeted Gene Transfer: Therapeutic Advances in Native Kidney Disease and Emerging Ex Vivo Allograft Engineering.",
  "title_text": "Kidney-Targeted Gene Transfer: Therapeutic Advances in Native Kidney Disease and Emerging Ex Vivo Allograft Engineering.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/1mjcg1p6y7hze",
  "venue": "Genes",
  "versions": []
}