{
  "abstract": "A complete cell type transcriptome atlas of a vertebrate could promote understanding of animal cell type composition, organization, and evolution. The miniaturized, transparent, and regenerative teleost Danionella cerebrum brings whole-vertebrate single-cell profiling experiments within reach. We performed region-stratified single-cell RNA sequencing across the adult Danionella body and mapped cell types and gene expression at single-cell resolution using spatial transcriptomics. We delineated spatially distinct neural cell types on the basis of their regional gene expression signatures. The body-wide atlas elucidated cell types harboring adult molecular positional memory, uncovered paedomorphic features, and revealed conserved body-region and appendage-specification programs in adult connective tissue. Comparative analyses revealed conserved neural cell types, and regeneration datasets uncovered expression dynamics during telencephalon regeneration. This whole-vertebrate transcriptome atlas yields a comprehensive resource for myriad questions in biology and neuroscience.",
  "abstract_shown": true,
  "affiliations": [
    "Whitehead Institute for Biomedical Research, Cambridge, MA, USA",
    "Einstein Center for Neurosciences, NeuroCure Cluster of Excellence, Charité–Universitätsmedizin Berlin, Berlin, Germany",
    "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA",
    "Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kutay Deniz Atabay",
      "orcid": "0000-0001-6920-5053"
    },
    {
      "affs": [
        0
      ],
      "name": "Patrick Aoude",
      "orcid": "0000-0003-0681-4438"
    },
    {
      "affs": [
        0
      ],
      "name": "Chanyoung Park",
      "orcid": "0000-0002-6186-2566"
    },
    {
      "affs": [
        1
      ],
      "name": "Mykola Kadobianskyi",
      "orcid": "0000-0003-1673-7181"
    },
    {
      "affs": [
        0
      ],
      "name": "Olivier H. Paugois"
    },
    {
      "affs": [
        1
      ],
      "name": "Benjamin Judkewitz",
      "orcid": "0000-0002-8570-3869"
    },
    {
      "affs": [
        2,
        3,
        0
      ],
      "name": "Peter W. Reddien",
      "orcid": "0000-0002-5569-333X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1mjjn5qw4sphx.bib",
  "cited_by": 6,
  "doi": "10.1126/science.aeg1125",
  "fulltext_url": null,
  "id": "1mjjn5qw4sphx",
  "issns": [
    "0036-8075",
    "0193-4511",
    "1095-9203"
  ],
  "landing_url": "https://doi.org/10.1126/science.aeg1125",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Single-cell and spatial transcriptomics"
    ]
  ],
  "openalex": "W7127965826",
  "pdf_url": null,
  "pmcid": "PMC13404894",
  "pmid": "42523349",
  "published": "2026-10-29",
  "publisher": "American Association for the Advancement of Science",
  "ris": "https://research.draconitic.com/paper/1mjjn5qw4sphx.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T13:20:39Z",
      "native_id": "W7127965826",
      "source": "openalex",
      "url": "https://doi.org/10.1126/science.aeg1125"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Whole-body single-cell atlas of an adult vertebrate, Danionella cerebrum",
  "title_text": "Whole-body single-cell atlas of an adult vertebrate, Danionella cerebrum",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T13:20:30Z",
  "url": "https://research.draconitic.com/paper/1mjjn5qw4sphx",
  "venue": "Science",
  "versions": []
}