{
  "abstract": "Importance: Diabetic foot ulcers (DFUs) are common complications of diabetes, a disease increasing in prevalence worldwide. Novel adjunctive treatments that are affordable and feasible to implement in both high- and low-income settings are urgently needed.\n\nObjective: To assess whether the inforatio technique promotes healing of DFUs compared with standard of care (SOC).\n\nDesign, Setting, and Participants: This multicenter, evaluator-blinded randomized clinical trial was conducted at 4 outpatient clinics specializing in wound care in Denmark from February 15, 2022, to December 18, 2024. One-year medical record follow-up was completed August 14, 2025. Participants included patients with noninfected Wagner grade 1 DFUs.\n\nInterventions: Participants were randomized 1:1 to receive the inforatio technique every third week for 12 weeks with SOC or SOC only. The inforatio technique involved making incisions on wound beds with 2-mm biopsy punch tools.\n\nMain Outcomes and Measures: The primary outcome was the proportion of ulcers achieving closure within 20 weeks. Secondary outcomes were health-related and disease-specific quality of life. Safety outcomes included serious and target ulcer–related adverse events.\n\nResults: A total of 101 patients were randomized, of whom 100 had DFUs and were included in the primary analysis (49 in the inforatio group and 51 in the SOC only group; 85 men; mean [SD] age, 64.4 [11.4] years; median ulcer size, 0.76 [range, 0.09-23.23] cm ² ). Twenty-four patients in the inforatio group (49.0%) vs 14 in the SOC-only group (27.5%) achieved ulcer closure within 20 weeks (adjusted odds ratio, 3.01 [95% CI, 1.20-7.58]; P = .02). No between-group difference was found in quality of life change from baseline to 20 weeks. Within 20 weeks, 7 patients in the inforatio group vs 13 in the SOC-only group experienced the serious adverse events, including death, amputation, or target ulcer–related hospitalization (relative risk, 0.56 [95% CI, 0.24-1.29]; P = .25), and 16 patients in the inforatio group vs 30 in the SOC-only group experienced target ulcer–related adverse events (relative risk, 0.56 [95% CI, 0.35-0.88]; P = .02).\n\nConclusions and Relevance: In this randomized clinical trial, the inforatio technique improved DFU healing compared with SOC alone. Fewer ulcer-related adverse events were also observed with the inforatio technique, although this exploratory finding should be interpreted cautiously.\n\nTrial Registration: ClinicalTrials.gov Identifier: NCT05189470",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedic Surgery, Zealand University Hospital Køge, Køge, Denmark",
    "Department of Orthopedic Surgery, Nykøbing Falster Hospital, Nykøbing Falster, Denmark",
    "Department of Orthopedic Surgery, Herlev Hospital, Herlev, Denmark",
    "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Sahar Moeini"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Hans Gottlieb"
    },
    {
      "affs": [
        0
      ],
      "name": "Tue Smith Jørgensen"
    },
    {
      "affs": [
        0
      ],
      "name": "Malene Ringholm Bæk Larsen"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Stig Brorson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1mx3vf7frwwr2.bib",
  "cited_by": 0,
  "doi": "10.1001/jamanetworkopen.2026.42733",
  "fulltext_url": null,
  "id": "1mx3vf7frwwr2",
  "issns": [
    "2574-3805"
  ],
  "landing_url": "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2856345",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "American Medical Association (AMA)",
  "ris": "https://research.draconitic.com/paper/1mx3vf7frwwr2.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:38Z",
      "native_id": "10.1001/jamanetworkopen.2026.42733",
      "source": "crossref",
      "url": "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2856345"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2574-3805",
      "subfield": "general"
    }
  ],
  "title": "Inforatio Technique and Foot Ulcer Closure Among Patients With Diabetes",
  "title_text": "Inforatio Technique and Foot Ulcer Closure Among Patients With Diabetes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:38Z",
  "url": "https://research.draconitic.com/paper/1mx3vf7frwwr2",
  "venue": "JAMA Network Open",
  "versions": []
}