{
  "abstract": "Mitophagy and pyroptosis are central regulators of cell fate and inflammation, and they form a complex bidirectional network across many diseases. Mitophagy suppresses NLRP3 inflammasome activation by removing damaged mitochondria and thereby reducing mtROS and mtDNA release, which blocks pyroptosis. Conversely, pyroptosis can inhibit mitophagy by releasing inflammatory mediators and activating caspase-1, creating reinforcing or counterbalancing feedback loops. Signaling modules such as PINK1/Parkin, NOD2-RIPK2, Nrf2/HO-1, and AMPK critically modulate both mitophagy and pyroptosis. These processes interact broadly in organ injuries of the brain, liver, kidney, lung, bone, and heart to determine inflammation intensity and cell survival. Natural small molecules and traditional Chinese medicine that target the mitophagy–pyroptosis axis can modify pathological states including neurodegeneration, metabolic inflammation, and immune evasion, and thus represent a promising strategy for precision therapy.",
  "abstract_shown": true,
  "affiliations": [
    "School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University",
    "State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University",
    "Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiaqi Ban"
    },
    {
      "affs": [
        0
      ],
      "name": "Ranxing Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Lihong Ao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hua Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Jun Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Yungeng Wei"
    },
    {
      "affs": [
        2
      ],
      "name": "Guichuan Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1mzqqqa43w0bc.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1950578",
  "fulltext_url": "https://europepmc.org/articles/PMC13710935",
  "id": "1mzqqqa43w0bc",
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  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1950578/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
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      "openalex",
      "1312|Inflammasome and immune disorders"
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  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1950578/pdf",
  "pmcid": "PMC13710935",
  "pmid": "42948245",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/1mzqqqa43w0bc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1950578",
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      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1950578/full"
    },
    {
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      "first_seen": "2026-10-31T12:21:48Z",
      "native_id": "PMC13710935",
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      "url": "https://doi.org/10.3389/fimmu.2026.1950578"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Inflammasome and immune disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Unraveling the pyroptosis-mitophagy axis: from molecular mechanisms to therapeutic opportunities",
  "title_text": "Unraveling the pyroptosis-mitophagy axis: from molecular mechanisms to therapeutic opportunities",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:48Z",
  "url": "https://research.draconitic.com/paper/1mzqqqa43w0bc",
  "venue": "Frontiers in Immunology",
  "versions": []
}