{
  "abstract": "Background: Ischemic heart disease (IHD) is the leading cause of global morbidity and mortality, underscoring an urgent need for innovative therapeutic strategies. Panax ginseng C. A. Meyer , a cornerstone herb in traditional medicine with exceptional pharmacological value, is widely regarded as the ''King of Herbs''. Ginsenoside Rg1 (G-Rg1), one of the principal bioactive protopanaxatriol-type saponins isolated from Panax ginseng C. A. Meyer , exhibits well-documented cardioprotective effects. However, a systematic and quantitative synthesis of its efficacy and mechanisms in preclinical IHD models is still lacking. Methods: In this study, we conducted a preclinical systematic review to evaluate the efficacy of G-Rg1 in animal models of IHD and to synthesize current evidence on its underlying mechanisms. A search of four major biomedical databases from inception to May 2026 identified nine eligible studies (236 animals). Methodological quality, rigorously assessed using the 9-item CAMARADES checklist, yielded scores of 4 to 6, indicating moderate overall quality. Data were pooled and analyzed using RevMan 5.3. Results: Meta-analysis showed that G-Rg1 administration reduced myocardial infarct size and decreased plasma levels of cardiac injury biomarkers (creatine kinase-MB [CK-MB] and N-terminal pro-brain natriuretic peptide [NT-proBNP]), and improved key functional parameters. One study reported that G-Rg1 attenuated the inducibility of ventricular tachyarrhythmias following ischemia-reperfusion injury. Mechanistically, the cardioprotective effects of G-Rg1 were consistently associated with anti-inflammatory, anti-apoptotic and mitochondrial protection pathways. Conclusion: These preclinical findings support future translational research and provide a basis for subsequent clinical studies on G-Rg1 in IHD.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, 341099, China; School of Pharmacy, Gannan Medical University, Ganzhou, 341000, China",
    "School of Pharmacy, Gannan Medical University, Ganzhou, 341000, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
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        0
      ],
      "name": "Jiaxin Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Sanjian Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yujie Zhang"
    },
    {
      "name": "Ziyou Liu"
    },
    {
      "name": "Yuting Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1n0x76p1c845j.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jgr.2026.101126",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S1226845326001521",
  "id": "1n0x76p1c845j",
  "issns": [
    "1226-8453",
    "2093-4947"
  ],
  "landing_url": "https://doi.org/10.1016/j.jgr.2026.101126",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
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      "lcc",
      "QK1-989"
    ],
    [
      "openalex",
      "1312|Ginseng Biological Effects and Applications"
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  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S1226845326001521/pdf",
  "pmcid": "PMC13711392",
  "pmid": "42948154",
  "published": "2026-08-17",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/1n0x76p1c845j.ris",
  "sources": [
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      "first_seen": "2026-10-30T13:43:37Z",
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      "url": "https://doi.org/10.1016/j.jgr.2026.101126"
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    {
      "first_seen": "2026-10-31T00:20:35Z",
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      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948154"
    },
    {
      "first_seen": "2026-10-31T12:22:10Z",
      "native_id": "PMC13711392",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jgr.2026.101126"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Ginseng Biological Effects and Applications",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Ginsenoside Rg1 for ischemic heart disease injury: preclinical evidence and possible mechanisms",
  "title_text": "Ginsenoside Rg1 for ischemic heart disease injury: preclinical evidence and possible mechanisms",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:10Z",
  "url": "https://research.draconitic.com/paper/1n0x76p1c845j",
  "venue": "Journal of Ginseng Research",
  "versions": []
}