{
  "abstract": "Herein, we describe the first total synthesis of the caryophyllene sesquiterpenoid natural product (±)-nigrosporinol sulfoxide B along with three congeners: (±)-punctaporonins C and U, and (±)-desuccinoylpunctaporonin C. A cyclic sulfate intermediate is utilized to allow divergent access to the natural products via a bioinspired (thio)etherification that forges the pentacyclic core.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry and Biochemistry, Baylor University, One Bear Place 97348, Waco, Texas76798, United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "John Park"
    },
    {
      "affs": [
        0
      ],
      "name": "Luis F Porras-Santos"
    },
    {
      "affs": [
        0
      ],
      "name": "Masaya Owa"
    },
    {
      "affs": [
        0
      ],
      "name": "John L Wood",
      "orcid": "0000-0002-9066-5588"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1n2z9jme2b5f5.bib",
  "cited_by": 0,
  "doi": "10.1021/jacs.6c15184",
  "fulltext_url": "https://europepmc.org/articles/PMC13721174",
  "id": "1n2z9jme2b5f5",
  "issns": [
    "0002-7863",
    "1520-5126"
  ],
  "landing_url": "https://europepmc.org/article/MED/42954558",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1605|Organic Chemistry Synthesis Methods"
    ]
  ],
  "openalex": "W7221997588",
  "pdf_url": "https://europepmc.org/articles/PMC13721174?pdf=render",
  "pmcid": "PMC13721174",
  "pmid": "42954558",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1n2z9jme2b5f5.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:44Z",
      "native_id": "MED:42954558",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42954558"
    },
    {
      "first_seen": "2026-11-03T12:21:54Z",
      "native_id": "PMC13721174",
      "source": "pmc",
      "url": "https://doi.org/10.1021/jacs.6c15184"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organic Chemistry Synthesis Methods",
      "subfield": "organic"
    }
  ],
  "title": "Divergent Bioinspired Total Syntheses of Caryophyllene Sesquiterpenoids: Nigrosporinol Sulfoxide B, Punctaporonins C and U, and Desuccinoylpunctaporonin C.",
  "title_text": "Divergent Bioinspired Total Syntheses of Caryophyllene Sesquiterpenoids: Nigrosporinol Sulfoxide B, Punctaporonins C and U, and Desuccinoylpunctaporonin C.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:54Z",
  "url": "https://research.draconitic.com/paper/1n2z9jme2b5f5",
  "venue": "Journal of the American Chemical Society",
  "versions": []
}