{
  "abstract": "The anti-atherosclerotic effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are well-documented, yet the underlying molecular mechanisms, particularly via cross-organ crosstalk, remain unclear. Here, a high-fat diet-induced atherosclerosis (AS) model in ApoE –/– mice was constructed. Compared with controls, AS mice exhibited elevated serum total cholesterol, triglyceride and low-density lipoprotein cholesterol levels, along with reduced high-density lipoprotein cholesterol levels, impaired hepatic and cardiac function, enlarged aortic plaque area, and pronounced hepatic steatosis and cardiac lipid deposition. DHA/EPA intervention reversed these biochemical and histopathological abnormalities, and conferred superior hepatoprotection than Atorvastatin. Transcriptomics identified 1453 and 1663 differentially expressed genes in liver and aorta of AS mice, respectively. DHA/EPA up-regulated genes related to hepatic cholesterol metabolism and bile acid synthesis, and aortic genes encoding ABC transporters and PPAR signaling components. Conversely, they suppressed hepatic IL-17 signaling and endothelial adhesion molecules. MicroRNA quantification showed significant modulation of aortic miR-33a, miR-146a-3p, miR-155 and miR-223-3p levels, implicating regulation of lipid metabolism and inflammation. Collectively, these data indicate that DHA and EPA exert synergistic anti-atherosclerotic effects via the aorta-liver axis, regulating lipid metabolism, inflammation and vascular remodeling via a miR-30a/146a-3p/223-3p mediated network. These findings provide experimental and mechanistic supports for nutritional intervention of AS.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Department of Cardiology, The First Affiliated Hospital of Ningbo University",
    "Laboratory of Food Nutrition and Clinical Research, Institute of Seafood, Zhejiang Gongshang University",
    "Department of Cardiology, Central Laboratory of Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People’s Hospital",
    "Department of Cardiology, Jinhua Central Hospital",
    "Heart Center, Department of Cardiovascular Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Junli Feng"
    },
    {
      "affs": [
        1
      ],
      "name": "Yiran Jin"
    },
    {
      "affs": [
        1
      ],
      "name": "Yu Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yibin Mei"
    },
    {
      "affs": [
        3
      ],
      "name": "Yibin Pan"
    },
    {
      "affs": [
        1
      ],
      "name": "Qing Shen"
    },
    {
      "affs": [
        2
      ],
      "name": "Chunlai Zeng"
    },
    {
      "affs": [
        4
      ],
      "name": "Yong Cui"
    },
    {
      "affs": [
        0
      ],
      "name": "Ning Huangfu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1nprcxxg3b988.bib",
  "cited_by": 0,
  "doi": "10.1038/s41538-026-00920-6",
  "fulltext_url": "https://doi.org/10.1038/s41538-026-00920-6",
  "id": "1nprcxxg3b988",
  "issns": [
    "2396-8370"
  ],
  "landing_url": "https://doi.org/10.1038/s41538-026-00920-6",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "TP368-456"
    ],
    [
      "lcc",
      "TX341-641"
    ],
    [
      "openalex",
      "2916|Fatty Acid Research and Health"
    ]
  ],
  "openalex": "W7166454804",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/1nprcxxg3b988.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:18Z",
      "native_id": "13b27642b51f4fcfaf39ba8b700e956d",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41538-026-00920-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:TX341-641",
      "subfield": "nutrition"
    }
  ],
  "title": "DHA and EPA alleviate atherosclerosis by synergistically regulating the aorta–liver axis via miRNA networks",
  "title_text": "DHA and EPA alleviate atherosclerosis by synergistically regulating the aorta–liver axis via miRNA networks",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:18Z",
  "url": "https://research.draconitic.com/paper/1nprcxxg3b988",
  "venue": "npj Science of Food",
  "versions": []
}