{
  "abstract": "We previously found that, among three biotinylated heptapeptides (Peptide 1, Peptide 2, and Peptide 3) derived from the amino acid sequence of Asp-hemolysin, a protein toxin produced by Aspergillus fumigatus, Peptide 2, which contains a d-amino acid, exhibits potent anti-allergic activity in vitro and in vivo. In this study, we evaluated the effects of Peptide 2 on immunoglobulin E (IgE)-dependent allergic edema induced by ovalbumin (OVA) in OVA-specific IgE transgenic mice, IgE-independent allergic edema induced by compound 48/80 (C48/80), and nonallergic inflammatory edema induced by histamine, serotonin, bradykinin, zymosan A, and λ-carrageenan. Peptide 2 significantly suppressed both OVA-IgE- and C48/80-induced paw edema, indicating inhibitory effects on both IgE-dependent and -independent allergic responses. Peptide 2 also dose-dependently inhibited histamine-induced edema but did not affect serotonin-, bradykinin-, zymosan A-, or λ-carrageenan-induced edema. These findings indicate that Peptide 2 modulates IgE-dependent and -independent allergic responses involving mast cell activation and histamine-related pathways and may be a candidate for the development of selective anti-allergic agents.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Makoto Ohira"
    },
    {
      "name": "Hana Yuki"
    },
    {
      "name": "Miu Tsumuraya"
    },
    {
      "name": "Erika Nozaki"
    },
    {
      "name": "Ryoka Nukimizu"
    },
    {
      "name": "Tadahiro Etoh"
    },
    {
      "name": "Daisuke Uta"
    },
    {
      "name": "Tsukasa Matsumoto"
    },
    {
      "name": "Akira Sato"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1p4pezq7fk6xv.bib",
  "cited_by": 0,
  "doi": "10.1248/bpb.b26-00370",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00370/_article",
  "id": "1p4pezq7fk6xv",
  "issns": [
    "1347-5215",
    "0918-6158"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00370/_article",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/pharmacology-toxicology"
    ],
    [
      "openalex",
      "2403|Mast cells and histamine"
    ]
  ],
  "openalex": "W7215053502",
  "pdf_url": "https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00370/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1p4pezq7fk6xv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:32Z",
      "native_id": "10.1248/bpb.b26-00370",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00370/_article"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Mast cells and histamine",
      "subfield": "immunology"
    }
  ],
  "title": "A Biotinylated Heptapeptide Containing a D-Amino Acid Suppresses Both IgE-Dependent and -Independent Allergic Edema in Mice",
  "title_text": "A Biotinylated Heptapeptide Containing a D-Amino Acid Suppresses Both IgE-Dependent and -Independent Allergic Edema in Mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:32Z",
  "url": "https://research.draconitic.com/paper/1p4pezq7fk6xv",
  "venue": "Biological and Pharmaceutical Bulletin",
  "versions": []
}