{
  "abstract": "Time-restricted feeding has emerged as a promising non-pharmacological intervention for the management of metabolic disorders, particularly type 2 diabetes mellitus and its associated complications. Time-restricted feeding involves restricting food intake to a specific daily eating window while fasting for the remaining hours within 24 h. Furthermore, time-restricted feeding can be combined with specific dietary modifications to enhance its therapeutic benefits. Type 2 diabetes mellitus has been strongly linked to gut dysbiosis, adipose tissue dysfunction, chronic low-grade inflammation, metabolic dysfunction-associated steatotic liver disease, and an increased risk of acute pancreatitis. Given the rising global prevalence of type 2 diabetes mellitus, early intervention strategies are becoming increasingly important. Prediabetes, as an intermediate stage preceding type 2 diabetes mellitus, provides a critical opportunity to understand the mechanisms underlying disease progression and to develop effective preventive strategies. However, the effects of time-restricted feeding on gut dysbiosis, adipose tissue dysfunction, dysregulated inflammatory responses, metabolic dysfunction-associated steatotic liver disease and the risk of acute pancreatitis at prediabetic state remain incompletely understood. Therefore, this review summarizes the current evidence regarding the therapeutic potential of time-restricted feeding in the management of type 2 diabetes mellitus and its related complications, while highlighting areas that require further investigation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Human Physiology, School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sthembiso Msane",
      "orcid": "0000-0002-3365-5623"
    },
    {
      "affs": [
        0
      ],
      "name": "Andile Khathi",
      "orcid": "0000-0002-2246-0038"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1pf37pbd9ade0.bib",
  "cited_by": 0,
  "doi": "10.3390/cells15191831",
  "fulltext_url": null,
  "id": "1pf37pbd9ade0",
  "issns": [
    "2073-4409"
  ],
  "landing_url": "https://www.mdpi.com/2073-4409/15/19/1831",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Dietary Effects on Health"
    ]
  ],
  "openalex": "W7220931169",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/1pf37pbd9ade0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:02Z",
      "native_id": "10.3390/cells15191831",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4409/15/19/1831"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Dietary Effects on Health",
      "subfield": "physiology"
    }
  ],
  "title": "Targeting Gut Microbiota, Inflammation, and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: Therapeutic Strategies and the Emerging Role of Time-Restricted Feeding",
  "title_text": "Targeting Gut Microbiota, Inflammation, and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: Therapeutic Strategies and the Emerging Role of Time-Restricted Feeding",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:02Z",
  "url": "https://research.draconitic.com/paper/1pf37pbd9ade0",
  "venue": "Cells",
  "versions": []
}