{
  "abstract": "Background\n\nThis study aimed to investigate the effects of anodal transcranial direct current stimulation (A-tDCS) over the left Sylvian parietal temporal region (SPT) on picture naming and auditory comprehension, as well as changes in brain functional connectivity in post-stroke aphasic patients.Methods\n\nThis is a double-blind, sham-controlled, randomized controlled study. Sixty aphasic patients were randomly assigned to receive either active or sham tDCS over the SPT as well as speech-language therapy for four weeks. Standardized aphasia assessments and electroencephalogram (EEG) examinations were conducted before and after the treatment. The EEG nonlinear index of cross approximate entropy (C-ApEn) was used to assess brain functional connectivity.Results\n\nThe tDCS group demonstrated significantly greater improvements than the control group in both picture naming and auditory word-picture identification scores (p < 0.001). Regression analysis revealed that the group (tDCS/control) was the primary factor associated with improving picture naming. The functional connectivity of F3-P3, F7-P3, T3-T5, T5-P3, T5-C3, T4-T6, T3-T4, and T5-T6 significantly increased following tDCS.Conclusions\n\nAnodal tDCS over the left SPT can improve picture naming and auditory comprehension in subacute post-stroke aphasia. Potential mechanisms include enhanced connectivity within the left-hemisphere dorsal/ventral streams, the executive control network, and between the bilateral temporal lobes. These functional connectivity changes provide neural evidence for the effect of tDCS on naming improvement. Clinical trial registry number ChiCTR-TRC-14005072.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Rehabilitation, Wangjing Hospital of China Academy of Chinese Medical Science, Beijing, China.",
    "Department of Chinese Medicine, Beijing Tongzhou District Majuqiao Community Health Service Center, Beijing, China.",
    "Department of Rehabilitation, Xuanwu Hospital Capital Medical University, Beijing, China.",
    "Department of Rehabilitation, Xuanwu Hospital Capital Medical University, Beijing, China. wangjiest@aliyun.com.",
    "Department of Rehabilitation, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. chenshirley@126.com.",
    "Department of Rehabilitation, Wangjing Hospital of China Academy of Chinese Medical Science, Beijing, China. wudongyu73@hotmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiayi Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Jin Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuanyuan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xu Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Ying Yuan"
    },
    {
      "affs": [
        2
      ],
      "name": "Yinan Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Guoping Duan"
    },
    {
      "affs": [
        0
      ],
      "name": "Baohu Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiuyue Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingxia Ji"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing Guo"
    },
    {
      "affs": [
        3
      ],
      "name": "Jie Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Xueli Chen"
    },
    {
      "affs": [
        5
      ],
      "name": "Dongyu Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1pn1bxsf68c5p.bib",
  "cited_by": 0,
  "doi": "10.1186/s12984-026-02112-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13721467",
  "id": "1pn1bxsf68c5p",
  "issns": [
    "1743-0003"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958378",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2808|Transcranial Magnetic Stimulation Studies"
    ]
  ],
  "openalex": "W7172339364",
  "pdf_url": "https://europepmc.org/articles/PMC13721467?pdf=render",
  "pmcid": "PMC13721467",
  "pmid": "42958378",
  "published": "2026-08-03",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1pn1bxsf68c5p.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958378",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958378"
    },
    {
      "first_seen": "2026-11-03T12:22:09Z",
      "native_id": "PMC13721467",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12984-026-02112-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Transcranial Magnetic Stimulation Studies",
      "subfield": "neurology"
    }
  ],
  "title": "Improvement in naming with tDCS and alteration of functional connectivity in post-stroke aphasia: a randomized controlled trial.",
  "title_text": "Improvement in naming with tDCS and alteration of functional connectivity in post-stroke aphasia: a randomized controlled trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:09Z",
  "url": "https://research.draconitic.com/paper/1pn1bxsf68c5p",
  "venue": "Journal of neuroengineering and rehabilitation",
  "versions": []
}