{
  "abstract": null,
  "abstract_shown": false,
  "affiliations": [
    "University Hospital Schleswig-Holstein, Medical Clinic II, Luebeck, Germany; DZHK (German Centre for Cardiovascular Research), partner site North, Luebeck, Germ"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 29,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "E. Rawish"
    },
    {
      "name": "T. Rusack"
    },
    {
      "name": "P. R. Letsch"
    },
    {
      "name": "J. Inderhees"
    },
    {
      "name": "K. Haendler"
    },
    {
      "name": "C. Gragoll"
    },
    {
      "name": "J. C. Voran"
    },
    {
      "name": "M. Schneider"
    },
    {
      "name": "K. Kurz"
    },
    {
      "name": "M. R. Hosen"
    },
    {
      "name": "M. Behrensen"
    },
    {
      "name": "S. Denker"
    },
    {
      "name": "A. Kuenstner"
    },
    {
      "name": "T. Sauer"
    },
    {
      "name": "J. Duque-Escobar"
    },
    {
      "name": "T. Schmidt"
    },
    {
      "name": "D. Frank"
    },
    {
      "name": "T. Stiermaier"
    },
    {
      "name": "W. Raasch"
    },
    {
      "name": "O. J. Mueller"
    },
    {
      "name": "T. Zeller"
    },
    {
      "name": "H. S. Busch"
    },
    {
      "name": "T. Gemoll"
    },
    {
      "name": "C. Knosalla"
    },
    {
      "name": "M. Spielmann"
    },
    {
      "name": "Z. Aherrharou"
    },
    {
      "name": "S. A. Summers"
    },
    {
      "name": "I. Eitel"
    },
    {
      "name": "C. Frerker"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1pnjwtt2sx29k.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.07.757226",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757226v1.full",
  "id": "1pnjwtt2sx29k",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757226v1",
  "language": null,
  "licence": "LicenseRef-all-rights-reserved",
  "licence_label": "All rights reserved",
  "licence_source": "article",
  "licence_url": null,
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7220834596",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757226v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1pnjwtt2sx29k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:25Z",
      "native_id": "10.64898/2026.10.07.757226",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757226v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition",
  "title_text": "Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:25Z",
  "url": "https://research.draconitic.com/paper/1pnjwtt2sx29k",
  "venue": "bioRxiv",
  "versions": []
}