{
  "abstract": "Hepatoid adenocarcinoma of the lung (HAL) is a rare pulmonary malignancy that resembles hepatocellular carcinoma morphologically and poses diagnostic challenges, particularly when alpha-fetoprotein (AFP) is absent. We report a man in his 50s with chronic obstructive pulmonary disease and a solitary 1.9-cm right upper lobe nodule. Percutaneous biopsy identified non-small cell carcinoma without establishing the subtype. Video-assisted thoracoscopic right upper lobectomy with mediastinal lymphadenectomy revealed a hepatoid tumour expressing HepPar-1 and CK7 but not AFP, arginase-1 or glypican-3. The absence of a hepatic lesion on staging imaging supported a pulmonary primary. The tumour was pT1bN0 with no clinically detected metastases. At 6 months after resection, there was no evidence of recurrence. This case illustrates the limitations of small biopsies and isolated immunohistochemical markers in diagnosing an AFP-negative pulmonary hepatoid tumour.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pulmonology Coimbra Hospital and University Center Coimbra Portugal.",
    "Department of Pathology Coimbra Hospital and University Center Coimbra Portugal."
  ],
  "article_type": "case study",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cláudia Martinho",
      "orcid": "0009-0002-6872-2934"
    },
    {
      "affs": [
        0
      ],
      "name": "Miguel Afonso",
      "orcid": "0000-0001-5285-2203"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Vânia Almeida",
      "orcid": "0000-0002-2202-7402"
    },
    {
      "affs": [
        0
      ],
      "name": "João Couto",
      "orcid": "0000-0002-6415-5904"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandra Cunha"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1psh8cw19me0r.bib",
  "cited_by": 0,
  "doi": "10.1002/rcr2.70793",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717599/?tool=EBI",
  "id": "1psh8cw19me0r",
  "issns": [
    "2051-3380"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13717599",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2740|Metastasis and carcinoma case studies"
    ]
  ],
  "openalex": "W7224206693",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717599/pdf/?tool=EBI",
  "pmcid": "PMC13717599",
  "pmid": "42959788",
  "published": "2026-10-29",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/1psh8cw19me0r.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13717599",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717599"
    },
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42959788",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959788"
    },
    {
      "first_seen": "2026-11-02T12:21:53Z",
      "native_id": "PMC13717599",
      "source": "pmc",
      "url": "https://doi.org/10.1002/rcr2.70793"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Metastasis and carcinoma case studies",
      "subfield": "general"
    }
  ],
  "title": "Hepatoid Carcinoma of the Lung: A Rare Presentation",
  "title_text": "Hepatoid Carcinoma of the Lung: A Rare Presentation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:53Z",
  "url": "https://research.draconitic.com/paper/1psh8cw19me0r",
  "venue": "Respirology case reports",
  "versions": []
}