{
  "abstract": "Introduction: Stereotactic body radiotherapy (SBRT) to peripheral lung tumors is associated with radiation-induced bone effects that may predispose patients to chest wall pain and radiation-induced rib fractures. These effects may be inhibited by bisphosphonates. We aimed to determine the impact of risedronate on the radiologic biomarker of rib cortical thickness (CTh) in patients with peripheral lung tumors treated with SBRT. Methods: This randomized, double-blind, placebo-controlled phase 2 clinical trial enrolled patients with tumors within 2 cm of the chest wall, who were randomized 1:1 to receive risedronate 150 mg prior to SBRT or placebo. CTh was evaluated every 3 months for 1 year. The primary endpoint was the percent change in rib CTh from baseline to 3 months within the higher than 30 Gy isodose region. Results: Seventy-three patients (78 tumors) were randomized and eligible for analysis. Baseline CTh was 1.46 (± 0.34) mm and 1.44 (± 0.42) mm in the placebo and risedronate arms, respectively. The mean percent change from baseline to 3 months within the 30 Gy isodose region was 6.4% (± 18.0) for placebo versus 3.1% (± 17.9) for risedronate (absolute difference: −3.3%; p = 0.44). The absolute differences in percent CTh change from baseline to 6, 9, and 12 months in the risedronate (versus placebo) group were −4.7%, −8.3%, and −11.8%, respectively. Conclusion: In patients with peripheral lung tumors treated with SBRT, risedronate did not result in statistically significant differences in CTh within the 30 Gy isodose region. This biomarker of bone changes after SBRT demonstrated increases over time within higher dose regions in the placebo group but remained similar to baseline in the risedronate group. Further studies are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, North Carolina; Corresponding author. Address for correspondence: Ryan T. Hughes, MD, Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina.",
    "Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, North Carolina",
    "Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston Salem, North Carolina",
    "Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston Salem, North Carolina",
    "Department of Radiology, Wake Forest University School of Medicine, Winston Salem, North Carolina",
    "Department of Cancer Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina",
    "Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ryan T. Hughes, MD"
    },
    {
      "affs": [
        1
      ],
      "name": "Paul J. Black, PhD"
    },
    {
      "affs": [
        1
      ],
      "name": "India R. Wood, MS"
    },
    {
      "affs": [
        2
      ],
      "name": "Anna C. Snavely, PhD"
    },
    {
      "affs": [
        3
      ],
      "name": "Beverly J. Levine, PhD"
    },
    {
      "affs": [
        1
      ],
      "name": "Justin M. Napolitano, PhD"
    },
    {
      "affs": [
        1
      ],
      "name": "Heather D. Pacholke, MD"
    },
    {
      "affs": [
        4
      ],
      "name": "Janardhana Ponnatapura, MD"
    },
    {
      "affs": [
        4
      ],
      "name": "Kathryn E. Weaver, PhD"
    },
    {
      "affs": [
        5
      ],
      "name": "Glenn J. Lesser, MD"
    },
    {
      "affs": [
        6
      ],
      "name": "Sun H. Park, PhD"
    },
    {
      "affs": [
        1
      ],
      "name": "Jeffrey S. Willey, PhD"
    },
    {
      "affs": [
        1
      ],
      "name": "Michael K. Farris, MD"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1pvyftejnd60h.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jtocrr.2026.101069",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2666364326001207",
  "id": "1pvyftejnd60h",
  "issns": [
    "2666-3643"
  ],
  "landing_url": "https://doi.org/10.1016/j.jtocrr.2026.101069",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "2730|Bone health and treatments"
    ]
  ],
  "openalex": "W7204823424",
  "pdf_url": "https://www.jtocrr.org/article/S2666-3643(26)00120-7/pdf",
  "pmcid": null,
  "pmid": "42964859",
  "published": "2026-08-31",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/1pvyftejnd60h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:51Z",
      "native_id": "21bfe13003374456a9b4515f6bfd345d",
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      "url": "https://doi.org/10.1016/j.jtocrr.2026.101069"
    },
    {
      "first_seen": "2026-11-03T12:21:37Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Bone health and treatments",
      "subfield": "oncology"
    }
  ],
  "title": "Effect of Risedronate on Rib Cortical Thickness After Stereotactic Body Radiotherapy to Peripheral Lung Tumors: Results of a Randomized Phase 2 Trial",
  "title_text": "Effect of Risedronate on Rib Cortical Thickness After Stereotactic Body Radiotherapy to Peripheral Lung Tumors: Results of a Randomized Phase 2 Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:37Z",
  "url": "https://research.draconitic.com/paper/1pvyftejnd60h",
  "venue": "JTO Clinical and Research Reports",
  "versions": []
}