{
  "abstract": "Introduction\n\nPoor-grade aneurysmal subarachnoid hemorrhage (aSAH) is associated with high mortality and poor functional outcomes. Despite improved survival with advances in neurocritical care, long-term quality of life (QOL) and psychological sequelae remain insufficiently characterized.Research question\n\nWhat is the long-term quality of life among survivors of poor-grade aSAH and how is it associated with functional and psychological outcomes?Material and methods\n\nWe retrospectively analyzed patients with poor-grade aSAH (WFNS IV-V) treated between 2013 and 2023. Survivors underwent long-term follow-up assessment using the Stroke-Specific Quality of Life scale (SS-QOL), SF-12 Physical Component Summary (PCS), and Patient Health Questionnaire (PHQ-9). SS-QOL >147 was used as descriptive threshold.Results\n\nOf 339 patients with poor-grade aSAH, 47.8% died. Among survivors, 15.9% were lost to follow-up. Among eligible survivors, 35.8% did not participate, resulting in 79 included patients (23.3% of the original cohort; median follow-up of 4.36 years. Among participants, 88.6% had SS-QOL >147. SS-QOL correlated positively with SF-12 PCS (ρ = 0.49, p < 0.001) and negatively with PHQ-9 (ρ = -0.67, p < 0.001). In multivariable analysis, PHQ-9 was the only variable associated with SS-QOL. Higher depressive symptom burden was associated with lower scores across all SS-QOL domains.Discussion and conclusion\n\nAmong selected survivors of poor-grade aSAH, favorable QOL was observed despite severe initial disease. Depressive symptom burden was strongly associated with overall QOL, and inversely associated with all SS-QOL domains. However, mortality, loss to follow-up, and non-participation represent sources of selection bias and may result in overestimation of QOL.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, Düsseldorf University Hospital, Heinrich-Heine University Düsseldorf, Düsseldorf, North Rhine-Westphalia, 40225, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Isabel David"
    },
    {
      "affs": [
        0
      ],
      "name": "Ibrahim E Efe"
    },
    {
      "affs": [
        0
      ],
      "name": "Igor Fischer"
    },
    {
      "affs": [
        0
      ],
      "name": "David Wasilewski"
    },
    {
      "affs": [
        0
      ],
      "name": "Sihmehmet Sahan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yousef Abusabha"
    },
    {
      "affs": [
        0
      ],
      "name": "Milad Neyazi"
    },
    {
      "affs": [
        0
      ],
      "name": "Rajiv Kumar Khajuria"
    },
    {
      "affs": [
        0
      ],
      "name": "Katharina Faust"
    },
    {
      "affs": [
        0
      ],
      "name": "Sajjad Muhammad"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1pxz2jt599pe2.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bas.2026.107465",
  "fulltext_url": "https://europepmc.org/articles/PMC13682061",
  "id": "1pxz2jt599pe2",
  "issns": [
    "2772-5294"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903676",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Intracranial Aneurysms: Treatment and Complications"
    ]
  ],
  "openalex": "W7221163803",
  "pdf_url": "https://europepmc.org/articles/PMC13682061?pdf=render",
  "pmcid": "PMC13682061",
  "pmid": "42903676",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1pxz2jt599pe2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903676",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903676"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracranial Aneurysms: Treatment and Complications",
      "subfield": "neurology"
    }
  ],
  "title": "Long-term quality of life and depressive symptoms among survivors of poor-grade aneurysmal subarachnoid hemorrhage.",
  "title_text": "Long-term quality of life and depressive symptoms among survivors of poor-grade aneurysmal subarachnoid hemorrhage.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/1pxz2jt599pe2",
  "venue": "Brain & spine",
  "versions": []
}