{
  "abstract": "Background: Klebsiella pneumoniae is an opportunistic pathogen responsible for invasive infections. The rise of carbapenem-resistant K. pneumoniae , largely driven by acquisition of bla NDM genes, represents a global health threat. In French Polynesia, sporadic cases of NDM-producing Enterobacteriales have been reported. This study characterises the genomic features of NDM-producing K. pneumoniae isolates from French Polynesia and evaluates the roles of clonal expansion and mobile genetic element (MGE)-mediated horizontal gene transfer in bla NDM dissemination. Materials and methods: Between July 2006 and September 2021, 17 carbapenemase-producing K. pneumoniae isolates were identified among 715 clinical samples in Tahiti. Whole-genome sequencing using Illumina MiSeq and Oxford Nanopore technologies was performed. Results: Seven NDM-producing K. pneumoniae strains were identified, five bla NDM-1 and two bla NDM-9 variants. All were resistant to ertapenem (MICs 1 to > 32 mg/L), with three resistant to imipenem (MICs 8 to > 32 mg/L) and six to meropenem (MICs 2 to > 8 mg/L). A novel IS 26 -mediated composite transposon, Tn 7722 (16 246 bp), carrying bla NDM-1 , qnrS1 and aph(3 )-VI genes, was detected in four isolates on IncF and IncR plasmids. Tn 7722 -like elements were found in diverse bacterial genomes worldwide, suggesting that they facilitates bla NDM transmission across multiple species and regions. Conclusion: NDM-producing K. pneumoniae in French Polynesia remain sporadic but genetically diverse, without evidence of local outbreak. This suggests a contribution of plasmid and Tn 7722 -associated elements to the diversity and evolution of carbapenem resistance. Ongoing genomic surveillance is vital to track the evolution of high-risk clones and MGEs guiding effective containment.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Tram Vo"
    },
    {
      "name": "Aïcha Hamieh"
    },
    {
      "name": "Marc Levy"
    },
    {
      "name": "Pierre Pontarotti"
    },
    {
      "name": "Jean-Marc Rolain"
    },
    {
      "name": "Vicky Merhej"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1qcb6m1gy4p34.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jgar.2026.09.007",
  "fulltext_url": null,
  "id": "1qcb6m1gy4p34",
  "issns": [
    "2213-7165",
    "2213-7173"
  ],
  "landing_url": "https://amu.hal.science/hal-05848979v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "1.sdv.mp"
    ],
    [
      "hal",
      "2.sdv.mhep.csc"
    ],
    [
      "hal",
      "2.sdv.mhep.me"
    ],
    [
      "hal",
      "2.sdv.mhep.mi"
    ],
    [
      "hal",
      "2.sdv.mp.bac"
    ],
    [
      "hal",
      "2.sdv.mp.par"
    ],
    [
      "hal",
      "2.sdv.mp.vir"
    ],
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7133337571",
  "pdf_url": "https://amu.hal.science/hal-05848979/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-19",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/1qcb6m1gy4p34.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:20:18Z",
      "native_id": "hal-05848979",
      "source": "hal",
      "url": "https://amu.hal.science/hal-05848979v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.mp",
      "subfield": "microbiology"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.csc",
      "subfield": "cardiovascular"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.me",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Characterisation of the novel transposon Tn7722 harbouring blaNDM-1: Insights into the evolutionary dynamics of resistance in Klebsiella pneumoniae",
  "title_text": "Characterisation of the novel transposon Tn7722 harbouring blaNDM-1: Insights into the evolutionary dynamics of resistance in Klebsiella pneumoniae",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:48Z",
  "url": "https://research.draconitic.com/paper/1qcb6m1gy4p34",
  "venue": "Journal of Global Antimicrobial Resistance",
  "versions": []
}