{
  "abstract": "Lactotransferrin, also known as lactoferrin, is an iron binding glycoprotein that displays antiviral activity against many different infectious agents, including human immunodeficiency virus (HIV)-1. Lactotransferrin is present in the breast milk and in the female genitourinary mucosa and it has been hypothesised as a possible candidate to prevent mother-to-child HIV-1 transmission. To verify if two functional polymorphisms, Thr29Ala and Arg47Lys, in the lactotransferrin encoding gene (LTF) could affect HIV-1 infection and vertical transmission, a preliminary association study was performed in 238 HIV-1 positive and 99 HIV-1 negative children from Brazil, Italy, Africa and India. No statistically significant association for the Thr29Ala and Arg47Lys LTF polymorphisms and HIV-1 susceptibility in the studied populations was found. Additionally LTF polymorphisms frequencies were compared between the four different ethnic groups.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Luisa Zupin"
    },
    {
      "name": "Vania Polesello"
    },
    {
      "name": "Antonio Victor Campos Coelho"
    },
    {
      "name": "Michele Boniotto"
    },
    {
      "name": "Luiz Claudio Arraes"
    },
    {
      "name": "Sergio Crovella"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1qetrgzc67ssw.bib",
  "cited_by": 6,
  "doi": "10.1590/0074-02760140447",
  "fulltext_url": null,
  "id": "1qetrgzc67ssw",
  "issns": [
    "0074-0276",
    "1678-8060"
  ],
  "landing_url": "https://hal.science/hal-05797369v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2406|HIV Research and Treatment"
    ]
  ],
  "openalex": "W2085281126",
  "pdf_url": "https://www.scielo.br/j/mioc/a/wPjrJsZzj3PHpzcXkLrGz6v/?lang=en&format=pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-13",
  "publisher": "Instituto Oswaldo Cruz, Ministério da Saúde",
  "ris": "https://research.draconitic.com/paper/1qetrgzc67ssw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "hal-05797369",
      "source": "hal",
      "url": "https://hal.science/hal-05797369v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2406|HIV Research and Treatment",
      "subfield": "microbiology"
    }
  ],
  "title": "Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups",
  "title_text": "Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/1qetrgzc67ssw",
  "venue": "Memórias do Instituto Oswaldo Cruz",
  "versions": []
}