{
  "abstract": "Panic disorder associates with altered fear circuitry, autonomic dysregulation and stress-related immune perturbations, yet its molecular and treatment-response signatures remain poorly defined. Internet-delivered cognitive behavioral therapy (iCBT) is an effective first-line treatment with unexplained outcome variations across individuals. Here, we report altered profiles of small non-coding RNAs in peripheral blood mononuclear cells from panic disorder patients before and after iCBT, compared with longitudinally sampled healthy controls. Thirteen top-ranking microRNAs discriminated patients from controls and separated pre- and post-treatment states, both of which differed from controls. Correspondingly, baseline hsa-miR-125b-5p levels were significantly associated with post-iCBT symptom improvement. Transfer RNA-derived fragments (tRFs) showed even greater discriminatory power, with nuclear-Val-3'-tRF family members exhibiting a pronounced post-treatment shift. Pathway analyses of panic disorder-associated and CBT-responsive small RNA targets converged on immune-related pathways, supporting a role in inflammatory mechanisms and highlighting blood small non-coding RNAs as promising biomarkers of panic disorder and its therapeutic response.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Faculty of Mathematics and Science, and the Edmond and Lily Safra Ce"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "S. Vaknine Treidel"
    },
    {
      "name": "A. Halaj"
    },
    {
      "name": "L. Mitzva"
    },
    {
      "name": "T. Goltser-Dubner"
    },
    {
      "name": "A. Strauss"
    },
    {
      "name": "B. Gelchinsky-Karagichev"
    },
    {
      "name": "D. Pevzner"
    },
    {
      "name": "O. Oz"
    },
    {
      "name": "R. Amer"
    },
    {
      "name": "M. Lavon"
    },
    {
      "name": "O. Gadish"
    },
    {
      "name": "E. R. Bennett"
    },
    {
      "name": "D. S. Greenberg"
    },
    {
      "name": "L. Carmel"
    },
    {
      "name": "S. Israel"
    },
    {
      "name": "R. Segman"
    },
    {
      "name": "J. D. Huppert"
    },
    {
      "affs": [
        0
      ],
      "name": "H. Soreq"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1qp2gbnq5pt1p.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.03.749122",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.03.749122v1.full",
  "id": "1qp2gbnq5pt1p",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.03.749122v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ],
    [
      "openalex",
      "3205|Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes"
    ]
  ],
  "openalex": "W7211913051",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.03.749122v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1qp2gbnq5pt1p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.64898/2026.09.03.749122",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.03.749122v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Internet-delivered cognitive behavioral therapy is associated with distinct blood small RNA profiles in panic disorder",
  "title_text": "Internet-delivered cognitive behavioral therapy is associated with distinct blood small RNA profiles in panic disorder",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:58Z",
  "url": "https://research.draconitic.com/paper/1qp2gbnq5pt1p",
  "venue": "bioRxiv",
  "versions": []
}