{
  "abstract": "The genus Peucedanum (Apiaceae) contains diverse coumarins and related secondary metabolites with a wide range of pharmacological activities; however, the antiviral potential of Korean taxa remains largely unexplored. In this study, we evaluated the cytotoxicity and anti-influenza activity of aerial-part extracts from Korean Peucedanum taxa and the allied species Sillaphyton podagraria. Twenty-six ethanol extracts, comprising 24 accessions representing eight identified taxa and two unidentified Peucedanum samples, were screened against influenza A/Puerto Rico/8/34 (H1N1) virus in MDCK cells. Cytotoxicity and antiviral activity were assessed using MTT-based assays, and the half-maximal inhibitory concentration (IC₅₀), half-maximal cytotoxic concentration (CC₅₀), and selectivity index (SI) were determined. Most extracts showed low cytotoxicity, with CC₅₀ values > 100 μg/mL. P. terebinthaceum var. deltoideum showed the strongest and most consistent activity across all three accessions, with IC₅₀ values of 6.42 to 12.18 μg/mL and SI values ranging from >8.21 to >15.57. One P. japonicum extract (Pj2) was also active (IC₅₀ = 15.52 μg/mL; SI > 6.44). Comparative chromatographic profiling further revealed taxon-specific chemical patterns. Collectively, these findings identify P. terebinthaceum var. deltoideum as a promising source of antiviral compounds and highlight the utility of a taxonomy-guided approach for bioprospecting and natural-product-based antiviral discovery.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.",
    "Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.",
    "Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea.",
    "Department of Biology, Chungbuk National University, Cheongju 28644, Republic of Korea.",
    "Animal Medical Institute, Chonnam National University, Gwangju 61186, Republic of Korea.",
    "Department of Veterinary Anatomy, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.",
    "Advanced-Basic-Convergence Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Gun Lee",
      "orcid": "0009-0003-5545-4464"
    },
    {
      "affs": [
        2
      ],
      "name": "Kyeonghee Kim"
    },
    {
      "affs": [
        2
      ],
      "name": "Seung Mok Ryu",
      "orcid": "0009-0001-6808-0524"
    },
    {
      "affs": [
        3
      ],
      "name": "Heewon Ji",
      "orcid": "0009-0008-2253-144X"
    },
    {
      "affs": [
        2
      ],
      "name": "Hyun Ji Lee"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hyeon Jeong Moon",
      "orcid": "0009-0007-0943-9297"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chung-Do Lee",
      "orcid": "0009-0002-1029-5669"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jaewoo Choi",
      "orcid": "0009-0001-6049-049X"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Yeong-Bin Baek",
      "orcid": "0000-0003-1703-7742"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Sang-Ik Park",
      "orcid": "0000-0003-1709-0324"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Joong-Sun Kim",
      "orcid": "0000-0003-2180-4860"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Jun-Gyu Park",
      "orcid": "0000-0001-7163-3591"
    },
    {
      "affs": [
        3,
        6
      ],
      "name": "Jun-Ho Song",
      "orcid": "0000-0002-8987-4710"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1qv0j96zjb9xv.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198676",
  "fulltext_url": "https://europepmc.org/articles/PMC13664839",
  "id": "1qv0j96zjb9xv",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883922",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Plant chemical constituents analysis"
    ]
  ],
  "openalex": "W7214576287",
  "pdf_url": "https://europepmc.org/articles/PMC13664839?pdf=render",
  "pmcid": "PMC13664839",
  "pmid": "42883922",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1qv0j96zjb9xv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883922",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883922"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant chemical constituents analysis",
      "subfield": "plant-biology"
    }
  ],
  "title": "Taxonomy-Guided Discovery of Antiviral Resources in Korean Peucedanum L. (Apiaceae).",
  "title_text": "Taxonomy-Guided Discovery of Antiviral Resources in Korean Peucedanum L. (Apiaceae).",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/1qv0j96zjb9xv",
  "venue": "International journal of molecular sciences",
  "versions": []
}