{
  "abstract": "Background\n\nHepatitis C virus (HCV) genotype 1b infection remains a leading cause of chronic liver disease despite advances in direct-acting antivirals (DAAs). Resistance-associated substitutions (RASs) in the non-structural 5 A (NS5A) region, particularly the Y93H mutation, have been associated with reduced antiviral susceptibility and variable treatment outcomes. The global baseline prevalence of this substitution in treatment-naïve populations has not been systematically characterized.Methods\n\nA systematic review and meta-analysis were conducted in accordance with PRISMA 2020 guidelines and registered with PROSPERO. Observational and randomized studies reporting baseline NS5A Y93H prevalence in treatment-naïve HCV genotype 1b patients were identified through PubMed, Embase, and Web of Science. Data were synthesized using a random-effects model, and heterogeneity was quantified by the I² statistic. Sensitivity and publication bias analyses were performed using leave-one-out and DOI plot methods.Results\n\nNine studies comprising 1,560 treatment-naïve patients from Asia and Europe, were included. The pooled prevalence of Y93H was 12% (95% CI, 6%-20%), with substantial heterogeneity (I² = 82.4%). Sensitivity analyses confirmed result stability, and minor asymmetry in the DOI plot suggested low publication bias.Conclusion\n\nThe Y93H substitution is a frequent naturally occurring variant in untreated HCV genotype 1b infection. Despite reduced clinical relevance with pangenotypic DAAs, its persistence warrants continued monitoring. Standardized sequencing and global resistance surveillance remain essential for optimizing treatment strategies and informing antiviral policy.Clinical trial number\n\nNot applicable.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology, Sharda University, Greater, Noida, India.",
    "Kookmin University, Seoul, 02707, South Korea.",
    "Department of Biotechnology, Graphic Era Deemed University, Dehradun, India.",
    "Centre for Promotion of Research, Graphic Era Hill University, Dehradun, India.",
    "Department of Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, Maharashtra, 411018, India.",
    "School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.",
    "Department of Pharmacology, NIET Pharmacy Institute, Greater, Noida, India.",
    "Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.",
    "Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Hyderabad, India.",
    "Saveetha Medical College & Hospital, Saveetha University, Chennai, India.",
    "Jawaharlal Nehru Medical College and Global Health Academy, School of Epidemiology and Public Health, Datta Meghe Institute of Higher Education, Wardha, India.",
    "University Centre for Research and Development, Chandigarh University, Mohali, Punjab, India. satapathyprakasini@gmail.com."
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dilip Kumar Kakru"
    },
    {
      "affs": [
        1
      ],
      "name": "Do-Youn Lee"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Navin Kumar"
    },
    {
      "affs": [
        4
      ],
      "name": "Rekha Arcot"
    },
    {
      "affs": [
        5
      ],
      "name": "Sorabh Lakhanpal"
    },
    {
      "affs": [
        6
      ],
      "name": "Saumya Das"
    },
    {
      "affs": [
        7
      ],
      "name": "Sanjay Kumar"
    },
    {
      "affs": [
        8
      ],
      "name": "Sushma Narsing Katkuri"
    },
    {
      "affs": [
        9
      ],
      "name": "Jeffrin Reneus Paul"
    },
    {
      "affs": [
        10
      ],
      "name": "Abhay M Gaidhane"
    },
    {
      "affs": [
        11
      ],
      "name": "Prakasini Satapathy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1qy1jjr48qkdg.bib",
  "cited_by": 0,
  "doi": "10.1186/s12879-026-14091-y",
  "fulltext_url": "https://europepmc.org/articles/PMC13685113",
  "id": "1qy1jjr48qkdg",
  "issns": [
    "1471-2334"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902253",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC109-216"
    ],
    [
      "openalex",
      "2721|Hepatitis C virus research"
    ]
  ],
  "openalex": "W7170513252",
  "pdf_url": "https://europepmc.org/articles/PMC13685113?pdf=render",
  "pmcid": "PMC13685113",
  "pmid": "42902253",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1qy1jjr48qkdg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42902253",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902253"
    },
    {
      "first_seen": "2026-10-30T13:45:36Z",
      "native_id": "a14bbec3650142f58f6c829f636f5feb",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12879-026-14091-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC109-216",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Prevalence of Y93H resistance-associated substitution in treatment-naïve hepatitis C virus genotype 1b patients: a systematic review and meta-analysis.",
  "title_text": "Prevalence of Y93H resistance-associated substitution in treatment-naïve hepatitis C virus genotype 1b patients: a systematic review and meta-analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:36Z",
  "url": "https://research.draconitic.com/paper/1qy1jjr48qkdg",
  "venue": "BMC infectious diseases",
  "versions": []
}