{
  "abstract": "Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and cancer. We explore the mechanistic contributions of EVs derived from skin, emphasizing their influence on immune modulation, senescence and tissue regeneration. We also examine their potential as diagnostic biomarkers and therapeutic agents, while addressing key technical and conceptual challenges that limit clinical translation. Drawing on collaborative insights from the COST Action NETSKINMODELS, we provide a set of recommendations to advance the field, including standardizing separation protocols, improving functional characterization and integrating with emerging technologies such as microneedles and 3D bioprinting. Together, these perspectives outline a strategic framework for unlocking the diagnostic and therapeutic potential of EVs in dermatological research and clinical care.",
  "abstract_shown": true,
  "affiliations": [
    "Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.",
    "Center for Molecular Biosciences, Innsbruck, Austria.",
    "Research Laboratories, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.",
    "Instituto de Biomedicina de Valencia IBV-CSIC, Valencia, Spain.",
    "Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.",
    "Biomaterials and Tissue Engineering Laboratory (bteLAB), Department of Chemistry, Faculty of Science, Ankara University, Ankara, Türkiye.",
    "Interdisciplinary Research Unit for Advanced Materials (INTRAM), Ankara University, Ankara, Türkiye.",
    "Department of Biophysics, Hamidiye Faculty of Medicine, University of Health Sciences, İstanbul, Türkiye.",
    "Laboratory of Cutaneous Physiopathology, San Gallicano Dermatological Institute - IRCCS, Rome, Italy.",
    "Institute for the Application of Nuclear Energy (INEP), Department of Reproductive Biology, University of Belgrade, Zemun, Serbia.",
    "Laboratory of Experimental and Translational Immunology, Intercollegiate Faculty of Biotechnology of the University of Gdańsk and the Medical University of Gdańsk, UG Institute of Biotechnology, Gdańsk, Poland.",
    "Research Unit of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ines Martic",
      "orcid": "0000-0002-6043-704X"
    },
    {
      "affs": [
        2
      ],
      "name": "Alessandro Paolini",
      "orcid": "0000-0003-4354-9100"
    },
    {
      "affs": [
        2
      ],
      "name": "Stefania Paola Bruno",
      "orcid": "0000-0002-0478-6296"
    },
    {
      "affs": [
        3
      ],
      "name": "Andrea Gallego",
      "orcid": "0000-0002-0006-6208"
    },
    {
      "affs": [
        4
      ],
      "name": "Dorottya Ádám",
      "orcid": "0000-0002-3543-4146"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Sedat Odabas",
      "orcid": "0000-0002-7844-7019"
    },
    {
      "affs": [
        7
      ],
      "name": "Şebnem Erçelen Ceylan",
      "orcid": "0000-0002-4954-4637"
    },
    {
      "affs": [
        8
      ],
      "name": "Emanuela Camera",
      "orcid": "0000-0001-6633-0449"
    },
    {
      "affs": [
        3
      ],
      "name": "Paloma Pérez",
      "orcid": "0000-0002-7166-2824"
    },
    {
      "affs": [
        4
      ],
      "name": "Attila Oláh",
      "orcid": "0000-0003-4122-5639"
    },
    {
      "affs": [
        2
      ],
      "name": "Andrea Masotti",
      "orcid": "0000-0002-2511-5088"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Mirjana Nacka-Aleksić",
      "orcid": "0000-0003-0750-9347"
    },
    {
      "affs": [
        10
      ],
      "name": "Danuta Gutowska-Owsiak",
      "orcid": "0000-0003-4503-2279"
    },
    {
      "affs": [
        11
      ],
      "name": "Nsrein Ali",
      "orcid": "0000-0001-9173-3717"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maria Cavinato",
      "orcid": "0000-0002-4891-9636"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1r4egsknfkk8w.bib",
  "cited_by": 0,
  "doi": "10.1111/exd.70375",
  "fulltext_url": "https://europepmc.org/articles/PMC13725834",
  "id": "1r4egsknfkk8w",
  "issns": [
    "0906-6705",
    "1600-0625"
  ],
  "landing_url": "https://europepmc.org/article/MED/42969279",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Innovative In Vitro Skin Organs for Basic and Translational Research"
    ],
    [
      "heading",
      "REVIEW ARTICLE"
    ],
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "1312|Extracellular vesicles in disease"
    ]
  ],
  "openalex": "W7225103765",
  "pdf_url": "https://europepmc.org/articles/PMC13725834?pdf=render",
  "pmcid": "PMC13725834",
  "pmid": "42969279",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1r4egsknfkk8w.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42969279",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42969279"
    },
    {
      "first_seen": "2026-11-05T12:22:17Z",
      "native_id": "PMC13725834",
      "source": "pmc",
      "url": "https://doi.org/10.1111/exd.70375"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Extracellular vesicles in disease",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?",
  "title_text": "Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:56Z",
  "url": "https://research.draconitic.com/paper/1r4egsknfkk8w",
  "venue": "Experimental dermatology",
  "versions": []
}