{
  "abstract": "Aberrant DNA methylation in peripheral blood has been proposed as a marker of breast cancer (BC) susceptibility. To determine whether BRCA1 promoter methylation reflects a broader constitutional methylation state, we performed genome-wide DNA methylation profiling in peripheral blood from 24 women with triple-negative breast cancer (TNBC) and 35 healthy controls, all carrying BRCA1 promoter methylation. Analysis using the Infinium MethylationEPIC BeadChip revealed no significant differences in global methylation patterns between groups. These findings suggest that BRCA1 promoter methylation represents a shared epigenetic state established before disease onset and largely unaffected by subsequent breast cancer development.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 70-204 Szczecin, Poland",
    "Regional Center for Digital Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland",
    "The Independent Clinical Epigenetics Laboratory, Pomeranian Medical University, 70-204 Szczecin, Poland",
    "Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, 70-204 Szczecin, Poland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Karolina Prajzendanc",
      "orcid": "0000-0002-9586-5685"
    },
    {
      "affs": [
        1
      ],
      "name": "Katarzyna Ewa Sokołowska"
    },
    {
      "affs": [
        2
      ],
      "name": "Tomasz Kazimierz Wojdacz"
    },
    {
      "affs": [
        0
      ],
      "name": "Jan Lubiński",
      "orcid": "0000-0003-2931-3003"
    },
    {
      "affs": [
        0
      ],
      "name": "Jacek Gronwald",
      "orcid": "0000-0002-3643-2871"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Anna Jakubowska",
      "orcid": "0000-0002-5650-0501"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1rcb878z5kc08.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209289",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705218/?tool=EBI",
  "id": "1rcb878z5kc08",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9289",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Epigenetics and DNA Methylation"
    ]
  ],
  "openalex": "W7222962804",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705218/pdf/?tool=EBI",
  "pmcid": "PMC13705218",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/1rcb878z5kc08.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27209289",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9289"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13705218",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705218"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Epigenetics and DNA Methylation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "BRCA1 Promoter Methylation Marks a Shared Blood Methylome State in Women with and Without Breast Cancer",
  "title_text": "BRCA1 Promoter Methylation Marks a Shared Blood Methylome State in Women with and Without Breast Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:31Z",
  "url": "https://research.draconitic.com/paper/1rcb878z5kc08",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}