{
  "abstract": "Special AT-rich binding protein 1 (SATB1) is a nuclear matrix-associated transcription factor that orchestrates higher-order chromatin architecture and gene expression in T and B lymphocytes. While SATB1’s role in T cells is well-established, its regulation and function in B cells remain underexplored. Here, we showed that Satb1 expression in mature B cells is controlled by alternative promoter usage and splicing, with promoters P1 and P3 dynamically switching upon LPS-induced activation, while P2 remains transcriptionally silent. We identified four Satb1 mRNA isoforms, including two novel transcripts ( Δ9 and Δ9Δ11 ), all of which maintain open reading frames. Satb1 transcription decreases upon activation while SATB1 protein content evolves differently, suggesting post-transcriptional regulation. SATB1 forms a high-molecular-weight complex in B cells, and co-immunoprecipitation mass spectrometry reveals RNA-binding proteins as its predominant interactors. These findings specify SATB1 expression kinetics during B-cell activation and reveal its role as a regulator of RNA splicing in B cells.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Jean-Yves Alejandro Frayssinhes"
    },
    {
      "name": "Lya Meriot"
    },
    {
      "name": "Tiffany Marchiol"
    },
    {
      "name": "Emilie Pinault"
    },
    {
      "name": "Thierry Forné"
    },
    {
      "name": "Charalampos Spilianakis"
    },
    {
      "name": "Eric Pinaud"
    },
    {
      "name": "Sandrine Le Noir"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1rfz7msyat2gf.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.07.22.739998",
  "fulltext_url": null,
  "id": "1rfz7msyat2gf",
  "issns": [],
  "landing_url": "https://hal.science/hal-05802449v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
  ],
  "openalex": "W7171258274",
  "pdf_url": "https://hal.science/hal-05802449/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1rfz7msyat2gf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:58Z",
      "native_id": "hal-05802449",
      "source": "hal",
      "url": "https://hal.science/hal-05802449v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Genomics and Chromatin Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Lineage-specific regulation and RNA-associated functions of SATB1 in mature B-cells",
  "title_text": "Lineage-specific regulation and RNA-associated functions of SATB1 in mature B-cells",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:58Z",
  "url": "https://research.draconitic.com/paper/1rfz7msyat2gf",
  "venue": "HAL",
  "versions": []
}