{
  "abstract": "Pulmonary abnormalities in chronic lymphocytic leukemia (CLL) usually reflect infection, pleural effusion, treatment toxicity, second malignancy, or Richter transformation. Leukemic pulmonary infiltration is underrecognized and radiologically heterogeneous. A 64-year-old man with CLL developed dyspnea, cough, and bilateral basal crazy-paving opacities on high-resolution computed tomography. Bronchoalveolar lavage showed lymphocytosis and a CD5-positive monoclonal B-cell population. Transbronchial lung cryobiopsy supported CLL infiltration and argued against mantle-cell lymphoma or transformation. Obinutuzumab plus venetoclax was followed by clinical improvement and regression of the interstitial lung opacities on follow-up imaging. This case supports combining BAL flow cytometry with tissue confirmation in this unusual pulmonary presentation. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory Medicine Limoges University Hospital University of Limoges Limoges France.",
    "Department of Hematology and Cellular Therapy University Hospital of Limoges Limoges France.",
    "Reference Center for Primary Amyloidosis and Other Immunoglobulin Deposition Diseases University Hospital of Limoges Limoges France."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Benoit Aguado"
    },
    {
      "affs": [
        0
      ],
      "name": "Florent Favard"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas Egenod"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Pedro De Lima Prata"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Arnaud Jaccard"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1rhete1nsk76c.bib",
  "cited_by": 0,
  "doi": "10.1002/jha2.70430",
  "fulltext_url": "https://europepmc.org/articles/PMC13685517",
  "id": "1rhete1nsk76c",
  "issns": [
    "2688-6146"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910155",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Chronic Lymphocytic Leukemia Research"
    ]
  ],
  "openalex": "W7223102596",
  "pdf_url": "https://europepmc.org/articles/PMC13685517?pdf=render",
  "pmcid": "PMC13685517",
  "pmid": "42910155",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1rhete1nsk76c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42910155",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910155"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Chronic Lymphocytic Leukemia Research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Pulmonary Involvement in Chronic Lymphocytic Leukemia: A Structured Diagnostic Approach to Diffuse Infiltrates-A Case Report.",
  "title_text": "Pulmonary Involvement in Chronic Lymphocytic Leukemia: A Structured Diagnostic Approach to Diffuse Infiltrates-A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/1rhete1nsk76c",
  "venue": "EJHaem",
  "versions": []
}