{
  "abstract": "Background and Aims. Antiphospholipid syndrome (APS) is a systemic autoimmune thromboinflammatory disorder characterized by thrombosis and/or pregnancy morbidity in association with antiphospholipid antibodies (aPL). As no single laboratory test serves as a diagnostic gold standard, non-criteria antibodies such as antiphosphatidylserine–prothrombin (aPS/PT) have been proposed to complement conventional testing, though their clinical utility remains inconsistently reported. This scoping review mapped the clinical and laboratory relevance of aPS/PT in APS, including seronegative APS, while identifying diagnostic gaps, methodological heterogeneity, and key uncertainties. Methods. A scoping review was conducted in accordance with PRISMA-ScR guidance and prospectively registered on the Open Science Framework (OSF; doi:10.17605/OSF.IO/FSJ8Z). A systematic search of PubMed, Scopus, Embase, and Web of Science identified 1,540 records using predefined strategies. After removal of 1,080 duplicates, title/abstract screening, and full-text review, 58 studies were selected for data extraction. Screening was performed using the Rayyan software. Data were extracted using a structured electronic form and synthesized descriptively. Results. A total of fifty-eight studies were incorporated, predominantly single-center (53 out of 58) and retrospective (34/58), spanning 1988–2023. The majority examined IgG and IgM aPS/PT (52/58), exhibiting considerable geographic and methodological heterogeneity. Only fourteen studies distinctly distinguished primary antiphospholipid syndrome (APS), secondary APS, non-APS, and disease controls, whereas most investigations depended on mixed or outcome-driven cohorts. Commercial assays were predominant (42 out of 58), primarily from Werfen; however, cut-off definitions varied considerably, even within identical kit types. Persistence and titers of aPS/PT were infrequently evaluated. Lupus anticoagulant was assessed in fifty-five studies employing diverse methodologies. Among thirty-five studies assessing concordance, aPS/PT demonstrated a positive correlation with lupus anticoagulant in thirty-one, although multivariable adjustment was uncommon. Associations with thrombosis and pregnancy morbidity were frequently reported but lacked consistent definitions and analytical approaches. Conclusions. aPS/PT demonstrates a reproducible trend toward association with APS-related laboratory and clinical outcomes; however, marked heterogeneity in cohort definitions, patient selection, assay platforms, cut-off determination, and limited multivariable analyses underscores substantial scope for methodological harmonization and standardized statistical approaches to improve confidence in interpreting this widely discussed non-criteria antibody.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Ariela Hoxha"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1rtbqygg45em3.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "https://www.btvb.org/btvb/article/view/802",
  "id": "1rtbqygg45em3",
  "issns": [
    "2785-5309"
  ],
  "landing_url": "https://www.btvb.org/btvb/article/view/802",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC666-701"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "PAGEPress Publications",
  "ris": "https://research.draconitic.com/paper/1rtbqygg45em3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:33Z",
      "native_id": "d672b5d243ed4d4f902b2b957edb65fb",
      "source": "doaj",
      "url": "https://www.btvb.org/btvb/article/view/802"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC666-701",
      "subfield": "cardiovascular"
    }
  ],
  "title": "CO100 | ANTIPHOSPHATIDYLSERINE–PROTHROMBIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME: CLINICAL ASSOCIATIONS AND DIAGNOSTIC GAPS MAPPED BY A SCOPING REVIEW",
  "title_text": "CO100 | ANTIPHOSPHATIDYLSERINE–PROTHROMBIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME: CLINICAL ASSOCIATIONS AND DIAGNOSTIC GAPS MAPPED BY A SCOPING REVIEW",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:33Z",
  "url": "https://research.draconitic.com/paper/1rtbqygg45em3",
  "venue": "Bleeding, Thrombosis and Vascular Biology",
  "versions": []
}