{
  "abstract": "Smoke inhalation injury (SII) dramatically elevates burn patient mortality. Although N6-methyladenosine (m6A) methylation is emerging as a central epitranscriptomic regulator of lung inflammation and injury, its specific involvement in SII remains unknown. Using an in vivo mouse SII model and smoke extract-treated MLE-12 cells, we show that smoke exposure downregulates the m6A writer-complex component WTAP and reduces global m6A methylation. WTAP knockdown attenuates epithelial inflammation, apoptosis, and STAT3 activation. Integrating transcriptomics with weighted gene co-expression network analysis (WGCNA) and MeRIP-qPCR, we identify pIgR as a downstream target: WTAP modifies m6A methylation within the 756/772 region of pIgR mRNA, and its knockdown prolongs pIgR mRNA half-life and elevates pIgR expression. pIgR silencing reverses the protection conferred by WTAP knockdown. These findings define a WTAP/m6A/pIgR axis that shapes the early epithelial response to smoke inhalation and identifies WTAP as a candidate therapeutic target for SII.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Jiaqi Li"
    },
    {
      "name": "Shengyu Huang"
    },
    {
      "name": "Guanghua Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1rz79xkqh2g2z.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117958",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722564/?tool=EBI",
  "id": "1rz79xkqh2g2z",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03341-9",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Molecular biology"
    ],
    [
      "heading",
      "Molecular interaction"
    ],
    [
      "heading",
      "Molecular mechanism of gene regulation"
    ],
    [
      "openalex",
      "1312|RNA modifications and cancer"
    ]
  ],
  "openalex": "W7223440620",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722564/pdf/?tool=EBI",
  "pmcid": "PMC13722564",
  "pmid": "42967003",
  "published": "2026-10-24",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/1rz79xkqh2g2z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117958",
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      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03341-9"
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      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117958",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226033419"
    },
    {
      "first_seen": "2026-11-02T03:21:51Z",
      "native_id": "PMC:PMC13722564",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722564"
    },
    {
      "first_seen": "2026-11-04T12:21:21Z",
      "native_id": "PMC13722564",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.117958"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:Molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "WTAP-mediated m6A methylation stabilizes pIgR mRNA and attenuates smoke-induced epithelial inflammation and apoptosis",
  "title_text": "WTAP-mediated m6A methylation stabilizes pIgR mRNA and attenuates smoke-induced epithelial inflammation and apoptosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:21Z",
  "url": "https://research.draconitic.com/paper/1rz79xkqh2g2z",
  "venue": "iScience",
  "versions": []
}